caa a22 4500 465767427 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00296115 doi (NATIONALLICENCE)springer-10.1007/BF00296115 Neuronal inputs to hippocampal formation in Alzheimer's disease and in parkinsonism-dementia complex on Guam [Elektronische Daten] [S. Goto, A. Hirano] Summary: This study concerns the expression of synaptophysin in the hippocampal formation of normal controls, of patients with Alzheimer's disease (AD) and of patients with parkinsonism-dementia complex on Guam (P-D complex). A monoclonal antibody was used to visualize synaptophysin, an integral component of presynaptic vesicle membranes. In the normal controls, a strong synaptophysin immunoreactivity was seen in the stratum pyramidale, stratum radiatum and stratum lacunosum-moleculare of the hippocampus proper, in the subiculum and in the molecular layer of the dentate gyrus. In the dentate gyrus molecular layer, the reaction product was distributed in a laminar fashion. By contrast, in AD and in P-D complex a significant decrease in immunoreactivity was observed in all hippocampal strata, and especially of the hippocampal subfield CA1 and the subiculum. In both diseases, synaptophysin expression was also diminished in the molecular layer of the dentate gyrus of all patients examined, with the inner portion exhibiting almost normal and the outer portion a strikingly reduced synaptophysin immunoreactivity. Springer-Verlag, 1990 Hippocampal formation nationallicence Alzheimer's disease nationallicence Parkinsonism-dementia complex on Guam nationallicence Synaptophysin nationallicence Goto S. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Hirano A. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 545-550 0001-6322 79:5<545 1990 79 401 https://doi.org/10.1007/BF00296115 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00296115 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goto S. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Hirano A. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 545-550 0001-6322 79:5<545 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer