caa a22 4500 465767443 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00296117 doi (NATIONALLICENCE)springer-10.1007/BF00296117 Alphaherpesvirus saimiri infection in rabbits [Elektronische Daten] 2. Morphometric studies of cutaneous spinal nerves [O. Illanes, S. Mossman, K. McCarthy] Summary: To provide a better insight into the ultrastructural pathology of herpetic neuropathy, quantitative studies were made on cutaneous spinal nerves of normal rabbits and rabbits intradermally infected with alphaherpesvirus saimiri (αHVS) isolate KM 322. Marked reductions in the numbers and densities of myelinated and unmyelinated axons were found in the nerves of the rabbits killed 17 and 45 days after the infection. Abnormalities in the size distribution of unmyelinated axons were seen at 45 days post-inoculation where axonal sprouting caused a noticeable shift in the fiber population. Two years after virus inoculation reduction in unmyelinated axons and abnormalities in the fiber size distributions characterized by smaller diameters of both myelinated and unmyelinated axons were detected. In these nerves conspicuous fibrosis caused a significant increase in the endoneurial area. At this stage of the infection regenerative changes involving myelinated fibers were found. Since attempts to detect spontaneous reactivation of αHVS infection in rabbits have been unsuccessful, the finding of regeneration 2 years after exposure seems in agreement with the view that regenerated myelinated fibers never attain their original size. In the present study although both types of fibers were damaged, morphometric data suggest that unmyelinated axons were more severely affected. Whether this seemingly selective involvement was due to spreading of the virus between axons sharing the same Schwann cell subunit remains to be proved. Springer-Verlag, 1990 Cutaneous nerves nationallicence Neuropathy nationallicence Herpesvirus nationallicence Morphometry nationallicence Rabbits nationallicence Illanes O. Department of Veterinary Anatomy, University of Liverpool, P.O. Box 147, L69 3BX, Liverpool, Great Britain aut Mossman S. Department of Medical Microbiology, University of Liverpool, P.O. Box 147, L69 3BX, Liverpool, Great Britain aut McCarthy K. Department of Medical Microbiology, University of Liverpool, P.O. Box 147, L69 3BX, Liverpool, Great Britain aut Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 558-565 0001-6322 79:5<558 1990 79 401 https://doi.org/10.1007/BF00296117 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00296117 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Illanes O. Department of Veterinary Anatomy, University of Liverpool, P.O. Box 147, L69 3BX, Liverpool, Great Britain aut NATIONALLICENCE 700 1- Mossman S. Department of Medical Microbiology, University of Liverpool, P.O. Box 147, L69 3BX, Liverpool, Great Britain aut NATIONALLICENCE 700 1- McCarthy K. Department of Medical Microbiology, University of Liverpool, P.O. Box 147, L69 3BX, Liverpool, Great Britain aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 558-565 0001-6322 79:5<558 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 465767303 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer