caa a22 4500 465767508 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00294220 doi (NATIONALLICENCE)springer-10.1007/BF00294220 Hippocampal neuronal density in temporal lobe epilepsy with and without gliomas [Elektronische Daten] [J. Kim, P. Guimaraes, M. Shen, L. Masukawa, D. Spencer] Summary: The majority of patients with temporal lobe epilepsy show hippocampal sclerosis, which pathologically represents neuronal loss and gliosis. We studied volumetric neuronal density on a representative mid to mid-posterior level slice of hippocampi surgically removed from intractable temporal lobe epilepsy cases, and compared the results between 25 non-tumor epilepsy (NTE) cases and 5 tumor-associated epilepsy (TAE) cases. Eleven age-matched non-epileptic autopsy cases were studied as controls. Cells were counted in the CA1 through CA4 fields and the stratum granulosum of the dentate fascia. In NTE every hippocampal field showed statistically significant loss of neurons, the neuronal density in each field ranging from 35% to 50% of that of control. The mean neuronal density between the TAE and NTE groups also showed statistically significant differences in all hippocampal fields. The neuronal density of hippocampal fields of NTE ranged from 43% to 58% of that of TAE. Tumor-associated epilepsy cases, however, failed to show any statistically significant deviation from the control in their neuronal density. The etiology of the difference in neuronal density between the TAE and NTE groups is discussed. Springer-Verlag, 1990 Temporal lobe epilepsy nationallicence Neuronal density nationallicence Hippocampus nationallicence Glioma nationallicence Hippocampal sclerosis nationallicence Kim J. Section of Neuropathology, Yale University School of Medicine, 06510, New Haven, CT, USA aut Guimaraes P. Section of Neuropathology, Yale University School of Medicine, 06510, New Haven, CT, USA aut Shen M. Section of Neuropathology, Yale University School of Medicine, 06510, New Haven, CT, USA aut Masukawa L. Department of Neurology, Graduate Hospital Research Center, 1 Graduate Plaza, 19146, Philadelphia, PA, USA aut Spencer D. Section of Neurosurgery, Yale University School of Medicine, 06510, New Haven, CT, USA aut Acta Neuropathologica Springer-Verlag 80/1(1990-05-01), 41-45 0001-6322 80:1<41 1990 80 401 https://doi.org/10.1007/BF00294220 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294220 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim J. Section of Neuropathology, Yale University School of Medicine, 06510, New Haven, CT, USA aut NATIONALLICENCE 700 1- Guimaraes P. Section of Neuropathology, Yale University School of Medicine, 06510, New Haven, CT, USA aut NATIONALLICENCE 700 1- Shen M. Section of Neuropathology, Yale University School of Medicine, 06510, New Haven, CT, USA aut NATIONALLICENCE 700 1- Masukawa L. Department of Neurology, Graduate Hospital Research Center, 1 Graduate Plaza, 19146, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Spencer D. Section of Neurosurgery, Yale University School of Medicine, 06510, New Haven, CT, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/1(1990-05-01), 41-45 0001-6322 80:1<41 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer