caa a22 4500 465767524 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00294219 doi (NATIONALLICENCE)springer-10.1007/BF00294219 The ontogenesis of Fcγ receptors and complement receptors CR1 in human peripheral nerve [Elektronische Daten] [C. Vedeler, E. Scarpini, S. Beretta, R. Doronzo, R. Matre] Summary: The ontogenesis of Fcγ receptors (FcR) and C3b/C4b receptors (CR1) was studied in peripheral nerves from ten fetuses aged from 20 to 38 weeks using immunohistochemical and functional assays. Monoclonal antibodies (mAbs) against FcR and CR1 stained nerve fibers at 10 weeks of gestation and the staining intensity increased during nerve maturation. FcR and CR1 are probably expressed on Schwann cells and are early markers during the development of peripheral nerves. Functional FcR activity was detected in nerve sections before initiation of myelination, which occurs at approximately 18-19 weeks, whereas functional CR1 activity was found in the sections after myelination. Functional CR1 activity may, therefore, be related to myelin. The ontogenesis of FcR and CR1 was also studied on Schwann cells in culture from three fetuses aged 14, 16 and 19 weeks, using immunofluorescence technique with mAbs. The FcR and CR1 are lost on cultured Schwann cells. This suggests that the receptors are not intrinsic to the cells or that Schwann cells require axonal contact for the expression of FcR and CR1. Springer-Verlag, 1990 Fetal nerve nationallicence Fcγ receptor nationallicence C3b/C4b receptor nationallicence Vedeler C. Broegelmann Research Laboratory for Microbiology, University of Bergen, Armauer Hansen Building, N-5021, Bergen, Norway aut Scarpini E. Department of Neurology, Dino Ferrari Center for Neuromuscular Diseases, University of Milan, Italy aut Beretta S. Department of Neurology, Dino Ferrari Center for Neuromuscular Diseases, University of Milan, Italy aut Doronzo R. Department of Neurology, Dino Ferrari Center for Neuromuscular Diseases, University of Milan, Italy aut Matre R. Broegelmann Research Laboratory for Microbiology, University of Bergen, Armauer Hansen Building, N-5021, Bergen, Norway aut Acta Neuropathologica Springer-Verlag 80/1(1990-05-01), 35-40 0001-6322 80:1<35 1990 80 401 https://doi.org/10.1007/BF00294219 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294219 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vedeler C. Broegelmann Research Laboratory for Microbiology, University of Bergen, Armauer Hansen Building, N-5021, Bergen, Norway aut NATIONALLICENCE 700 1- Scarpini E. Department of Neurology, Dino Ferrari Center for Neuromuscular Diseases, University of Milan, Italy aut NATIONALLICENCE 700 1- Beretta S. Department of Neurology, Dino Ferrari Center for Neuromuscular Diseases, University of Milan, Italy aut NATIONALLICENCE 700 1- Doronzo R. Department of Neurology, Dino Ferrari Center for Neuromuscular Diseases, University of Milan, Italy aut NATIONALLICENCE 700 1- Matre R. Broegelmann Research Laboratory for Microbiology, University of Bergen, Armauer Hansen Building, N-5021, Bergen, Norway aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/1(1990-05-01), 35-40 0001-6322 80:1<35 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer