caa a22 4500 465767540 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00294226 doi (NATIONALLICENCE)springer-10.1007/BF00294226 Necrosis of granule cells of hippocampus in adrenocortical failure [Elektronische Daten] [J. Mæhlen, A. Torvik] Summary: A case of untreated and rapidly progressive Addison's disease in a 23-year old woman showed selective necrosis with karyorhexis of the granule cells in the hippocampus. We suggest that this unique lesion was caused by a severe adrenocortical insufficiency. This explanation is in accordance with a recent report of selective loss of hippocampal granule cells after complete adrenalectomy in rats. No evidence of nerve cell loss was found in three cases of Addison's disease that had received cortisone treatment, which is consistent with the experimental observation that even very low levels of cortisone in adrenalectomized rats are sufficient to prevent granule cell loss. Springer-Verlag, 1990 Addison's disease nationallicence Adrenocortical failure nationallicence Neuropathology nationallicence Mæhlen J. Division of Neuropathology, Department of Pathology, Ullevål University Hospital, N-0407, Oslo 4, Norway aut Torvik A. Division of Neuropathology, Department of Pathology, Ullevål University Hospital, N-0407, Oslo 4, Norway aut Acta Neuropathologica Springer-Verlag 80/1(1990-05-01), 85-87 0001-6322 80:1<85 1990 80 401 https://doi.org/10.1007/BF00294226 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294226 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mæhlen J. Division of Neuropathology, Department of Pathology, Ullevål University Hospital, N-0407, Oslo 4, Norway aut NATIONALLICENCE 700 1- Torvik A. Division of Neuropathology, Department of Pathology, Ullevål University Hospital, N-0407, Oslo 4, Norway aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/1(1990-05-01), 85-87 0001-6322 80:1<85 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer