caa a22 4500 465767648 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00294228 doi (NATIONALLICENCE)springer-10.1007/BF00294228 Loss of neurons in the frontal cortex in AIDS brains [Elektronische Daten] [S. Ketzler, S. Weis, H. Haug, H. Budka] Summary: Neurons of Area 11 in the fronto-orbital cortex of 18 unselected AIDS brains are analyzed by means of stereology. Neurological abnormalities including dementing symptoms were described in eight patients. Neuropathology diagnosed human immunodeficiency virus (HIV)-specific changes in four, and diffuse poliodystrophy in eight brains. The majority (71.4%) of these brains was immunoreactive for HIV antigens when tested by immunocytochemistry. A significant loss of neurons is found as compared to normal controls. Neuronal density in AIDS brains is reduced by 18%, and the perikaryon volume fractions is reduced by 31%. Although only speculation on pathogenesis of this neuronal loss is possible at present, it may represent a part of the pathomorphological substrate of AIDS-related dementia. Moreover, it confirms by quantitative means damage to the cerebral cortex in AIDS which has been described only qualitatively as diffuse poliodystrophy. Springer-Verlag, 1990 Acquired immune deficiency syndrome (AIDS) nationallicence Cerebral cortex nationallicence Dementia nationallicence Morphometry nationallicence Neuronalloss nationallicence Ketzler S. Institut für Anatomie, Medizinische Universität Lübeck, D-2400, Lübeck, Federal Republic of Germany aut Weis S. Institut für Anatomie, Medizinische Universität Lübeck, D-2400, Lübeck, Federal Republic of Germany aut Haug H. Institut für Anatomie, Medizinische Universität Lübeck, D-2400, Lübeck, Federal Republic of Germany aut Budka H. Neurologisches Institut, Universität Wien, Wien, Austria aut Acta Neuropathologica Springer-Verlag 80/1(1990-05-01), 92-94 0001-6322 80:1<92 1990 80 401 https://doi.org/10.1007/BF00294228 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294228 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ketzler S. Institut für Anatomie, Medizinische Universität Lübeck, D-2400, Lübeck, Federal Republic of Germany aut NATIONALLICENCE 700 1- Weis S. Institut für Anatomie, Medizinische Universität Lübeck, D-2400, Lübeck, Federal Republic of Germany aut NATIONALLICENCE 700 1- Haug H. Institut für Anatomie, Medizinische Universität Lübeck, D-2400, Lübeck, Federal Republic of Germany aut NATIONALLICENCE 700 1- Budka H. Neurologisches Institut, Universität Wien, Wien, Austria aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/1(1990-05-01), 92-94 0001-6322 80:1<92 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer