caa a22 4500 465767672 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00307637 doi (NATIONALLICENCE)springer-10.1007/BF00307637 Evolution of post-natal Herpes simplex virus encephalitis to multicystic encephalopathy [Elektronische Daten] [Y. Chang, D. Soffer, D. Horoupian, L. Weiss] Summary: A 3-week-old, previously healthy infant developed biopsy-proven Herpes virus type 2 (HSV-2) encephalitis. The encephalitis was characterized by cells having intranuclear inclusions and was without evidence of inflammation or hemorrhage. Neuroimaging studies did not show any destructive lesions in the brain. In spite of antiviral therapy, the infant's neurological conditions deteriorated, and the patient died at the age of 18 weeks. Post-mortem examination showed that most of the cerebral hemispheres were replaced by multiloculated cystic cavities of various sizes, typical of multicystic encephalopathy (MCE). The cystic lesions were randomly distributed and were not confined to any vascular territory. By light microscopy, there were no features of viral infection in the brain. Although in situ hybridization of the biopsy specimen taken during the acute phase of the disease demonstrated abundant HSV genome, this same method failed to detect HSV on the post-mortem specimen. These findings suggest that HSV-2 can induce MCE. Furthermore, the absence of histological features of viral encephalitis and the failure to demonstrate viral genome in the brain at autopsy does not exclude an infections etiology in certain cases of MCE. Springer-Verlag, 1990 Herpes simplex encephalitis nationallicence Multicystic encephalopathy nationallicence In situ hybridization nationallicence Chang Y. Department of Pathology, Stanford University School of Medicine, 94305-5324, Stanford, CA, USA aut Soffer D. Department of Pathology, Stanford University School of Medicine, 94305-5324, Stanford, CA, USA aut Horoupian D. Department of Pathology, Stanford University School of Medicine, 94305-5324, Stanford, CA, USA aut Weiss L. Department of Pathology, Stanford University School of Medicine, 94305-5324, Stanford, CA, USA aut Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 666-670 0001-6322 80:6<666 1990 80 401 https://doi.org/10.1007/BF00307637 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307637 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chang Y. Department of Pathology, Stanford University School of Medicine, 94305-5324, Stanford, CA, USA aut NATIONALLICENCE 700 1- Soffer D. Department of Pathology, Stanford University School of Medicine, 94305-5324, Stanford, CA, USA aut NATIONALLICENCE 700 1- Horoupian D. Department of Pathology, Stanford University School of Medicine, 94305-5324, Stanford, CA, USA aut NATIONALLICENCE 700 1- Weiss L. Department of Pathology, Stanford University School of Medicine, 94305-5324, Stanford, CA, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 666-670 0001-6322 80:6<666 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer