caa a22 4500 465767680 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00307630 doi (NATIONALLICENCE)springer-10.1007/BF00307630 Senile plaques: staining for acetylcholinesterase and A4 protein: a comparative study in the hippocampus and entorhinal cortex [Elektronische Daten] [J. Ulrich, W. Meier-Ruge, A. Probst, E. Meier, S. Ipsen] Summary: In 20 unselected autopsy cases tissue blocks from the hippocampus with adjacent entorhinal cortex and neocortex were stained for acetylcholinesterase (AChE). From five brains shown to have large numbers of senile plaques tissue, adjacent to that taken for AChE tissue blocks, was embedded in paraffin and sections were immunostained for the A4 protein. The morphological aspects were compared. Equivalent types of plaques and plaque-like structures were observed in the A4- and ACHE-stained sections. On selected tissue blocks from patients with many senile plaques two immediately adjacent cryostat sections were stained, one for AChE and one for A4 protein. The same individual plaques could be identified on the two sections. These findings suggest that high AChE activity is intimately associated with the process of A4 protein formation and accumulation in plaques and that this association already occurs at a very carly stage of plaque formation. Springer-Verlag, 1990 Alzheimer's disease nationallicence A4 protein nationallicence Acetylcholinesterase nationallicence Senile plaque nationallicence Neuropathology nationallicence Ulrich J. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut Meier-Ruge W. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut Probst A. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut Meier E. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut Ipsen S. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 624-628 0001-6322 80:6<624 1990 80 401 https://doi.org/10.1007/BF00307630 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307630 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ulrich J. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut NATIONALLICENCE 700 1- Meier-Ruge W. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut NATIONALLICENCE 700 1- Probst A. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut NATIONALLICENCE 700 1- Meier E. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut NATIONALLICENCE 700 1- Ipsen S. Division of Neuropathology and Gerontological Brain Research, Institute of Pathology, CH-4003, Basel, Switzerland aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 624-628 0001-6322 80:6<624 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer