caa a22 4500 465767729 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00307631 doi (NATIONALLICENCE)springer-10.1007/BF00307631 Glucocorticoid therapy obscures the diagnosis of cerebral lymphoma [Elektronische Daten] [M. Geppert, C Ostertag, G. Seitz, M. Kiessling] Summary: Neuropathological and radiographical findings of two patients with primary CNS B cell lymphoma are presented. Prior to computerized tomographic (CT)-guided stereotactic biopsy both patients had received glucocorticoid therapy which led to marked tumor regression on CT scans and transient improvement of neurological deficits. Despite careful targeting and serial sampling, multiple biopsy specimens examined cytologically, histologically and immunomorphologically showed nonspecific reactive astrogliosis and conspicuous perivascular infiltrates of T lymphocytes. A second biopsy performed after an interval of 2 and 8 weeks, respectively, and short-term discontinuation of dexamethasone therapy in one case, unequivocally established the diagnosis of Non-Hodgkin lymphoma. It is concluded that steroid therapy may obscure the bioptic diagnosis of cerebral lymphoma. In addition to the well-known anti-edematous effect of glucocorticoids neuropathologists and neurosurgeons should be aware of a rapid and pronounced lymphodepletive action of steroids on maligant CNS lymphomas. Springer-Verlag, 1990 Brain tumor nationallicence Non-Hodgkin lymphoma nationallicence Primary cerebral lymphoma nationallicence Stereotactic biopsy nationallicence Glucocorticoid therapy nationallicence Geppert M. Institut für Pathologie, Universitäts-Klinikum, Universität des Saarlandes, D-6650, Homburg, Federal Republic of Germany aut Ostertag C. Abteilung für Stereotaktische Neurochirurgie, Universitäts-Klinikum, Universität des Saarlandes, D-6650, Homburg, Federal Republic of Germany aut Seitz G. Institut für Pathologie, Universitäts-Klinikum, Universität des Saarlandes, D-6650, Homburg, Federal Republic of Germany aut Kiessling M. Institut für Pathologie, Universitäts-Klinikum, Universität des Saarlandes, D-6650, Homburg, Federal Republic of Germany aut Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 629-634 0001-6322 80:6<629 1990 80 401 https://doi.org/10.1007/BF00307631 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307631 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Geppert M. Institut für Pathologie, Universitäts-Klinikum, Universität des Saarlandes, D-6650, Homburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Ostertag C. Abteilung für Stereotaktische Neurochirurgie, Universitäts-Klinikum, Universität des Saarlandes, D-6650, Homburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Seitz G. Institut für Pathologie, Universitäts-Klinikum, Universität des Saarlandes, D-6650, Homburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Kiessling M. Institut für Pathologie, Universitäts-Klinikum, Universität des Saarlandes, D-6650, Homburg, Federal Republic of Germany aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 629-634 0001-6322 80:6<629 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer