caa a22 4500 465767737 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00307625 doi (NATIONALLICENCE)springer-10.1007/BF00307625 Ultrastructural findings in spongy degeneration of white matter in silver foxes ( Vulpes vulpes ) [Elektronische Daten] A naturally occurring demyelinating disease with oligodendrocyte vacuolation [G. Hagen, W. Blakemore, I. Bjerkås] Summary: Spongy degeneration of white matter in silver foxes is a naturally occurring, hereditary disorder. We report ultrastructural findings in the upper cervical cord of five perfusion-fixed foxes that were examined between 5 weeks and 2 1/4 years after the onset of clinical signs. Large cytoplasmic vacuoles in oligodendrocytes were present in the foxes examined 5, 12 and 20 weeks after the onset. Other early features of the disease were severe vacuolation of myelin sheaths, demyelination, expansion of extracellular spaces and hypertrophy of astrocytes. Evidence of partial demyelination as well as demyelination of entire internodes was found. In the later stages of the disease, the vacuolation was largely resolved but a marked astrogliosis persisted and numerous remyelinated axons were present in the gliotic areas. Vacuolation of oligodendrocytes and partial demyelination has not previously been seen together in a single disease process. The relationship between oligodendrocyte vacuolation, myelin sheath vacuolation and demyelination is discussed. It is concluded that the present condition is due to a primary damage to oligodendrocytes; however, the underlying biochemical lesion is not known. Springer-Verlag, 1990 Oligodendrocyte nationallicence Astrocyte nationallicence Intramyelinic oedema nationallicence Demyelination nationallicence Remyelination nationallicence Hagen G. Department of Pathology, The Norwegian College of Veterinary Medicine, P.O. Box 8146 Dep., N-0033, Oslo 1, Norway aut Blakemore W. Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES, Cambridge, Great Britain aut Bjerkås I. Department of Anatomy, The Norwegian College of Veterinary Medicine, P.O. Box 8146 Dep., N-0033, Oslo 1, Norway aut Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 590-596 0001-6322 80:6<590 1990 80 401 https://doi.org/10.1007/BF00307625 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307625 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hagen G. Department of Pathology, The Norwegian College of Veterinary Medicine, P.O. Box 8146 Dep., N-0033, Oslo 1, Norway aut NATIONALLICENCE 700 1- Blakemore W. Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES, Cambridge, Great Britain aut NATIONALLICENCE 700 1- Bjerkås I. Department of Anatomy, The Norwegian College of Veterinary Medicine, P.O. Box 8146 Dep., N-0033, Oslo 1, Norway aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 590-596 0001-6322 80:6<590 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer