caa a22 4500 465767761 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00307633 doi (NATIONALLICENCE)springer-10.1007/BF00307633 Mosaicism of mitochondria in mitochondrial myopathy: an electronmicroscopic analysis of cytochrome c oxidase [Elektronische Daten] [K. Haginoya, S. Miyabayashi, K. Iinuma, K. Tada] Summary: Electron microscopic histochemistry was applied to the study of cytochrome c oxidase activity in each mitochondrion of biopsied muscles from four patients with mitochondrial myopathy [one case of fatal infantile mitochondrial myopathy, one case of myoclonus epilepsy associated with ragged-red fibers (MERRF), and two cases of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)]. In the patient with fatal infantile mitochondrial myopathy, intercellular heterogeneity of mitochondria was recognized. In the three patients with either MERRF or MELAS, cytochrome c oxidase activity was segmentally changed from positive to negative within single muscle fibers. In the two patients with MELAS, small groups of positive-stained mitochondria were located among negative-stained mitochondria in the negative segment of a few muscle fibers. These findings revealed that there were heterogeneous populations of normal and abnormal mitochondria intracellularly or intercellularly within the muscles of these patients. Springer-Verlag, 1990 Mitochondrial myopathy nationallicence Cytochrome c oxidase nationallicence Mosaicism of mitochondria nationallicence Electron microscopic histochemistry nationallicence Haginoya K. Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan aut Miyabayashi S. Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan aut Iinuma K. Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan aut Tada K. Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan aut Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 642-648 0001-6322 80:6<642 1990 80 401 https://doi.org/10.1007/BF00307633 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307633 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haginoya K. Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Miyabayashi S. Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Iinuma K. Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Tada K. Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 642-648 0001-6322 80:6<642 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer