caa a22 4500 465767788 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00307623 doi (NATIONALLICENCE)springer-10.1007/BF00307623 Senile dementia of Alzheimer type characterized by laminar neuronal loss exclusively in the hippocampus, parahippocampus and medial occipitotemporal cortex [Elektronische Daten] [T. Mizutani, N. Amano, H. Sasaki, Y. Morimatsu, H. Mori, M. Yoshimura, H. Yamanouchi, K. Hayakawa, H. Shimada] Summary: Seven cases of senile dementia of Alzheimer type (SDAT) with unusual clinico-pathological findings are reported. The patients showed neuronal loss in laminar pattern, with gliosis exclusively confined to the CA1 of the hippocampus, the area of the hippocampal gyrus (entorhinal cortex) and medial occipitotemporal cortex. This change was more pronounced in the oral region. The subcortical white matter showed more pronounced fibrillary gliosis than loss of myelin. Both Alzheimer's neurofibrillary tangles and senile plaques were less marked than those usually seen in SDAT. The mental disturbance started after the age of 65 in all patients. The main clinical feature was marked character change in addition to disturbance of cognitive function. Cranial computed tomography showed marked dilatation of the oral portion of the inferior horn of the lateral ventricle in the early stage. It was apparent that although the cases in this group could be incorporated within in the spectrum of SDAT, they could also be considered to represent a variant of SDAT. This group could contribute to an understanding of the clinico-pathological spectrum of SDAT as well as indicating ways of managing such patients. Springer-Verlag, 1990 Senile dementia of Alzheimer's type nationallicence Alzheimer's disease nationallicence Pick's disease nationallicence Laminar neuronal loss nationallicence Limbic system nationallicence Mizutani T. Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173, Tokyo, Japan aut Amano N. Department of Psychiatry, Kanagawa Rehabilitation Centre, Hokkaido University, Sapporo, Japan aut Sasaki H. Department of Neurology, School of Medicine, Hokkaido University, Sapporo, Japan aut Morimatsu Y. Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neurosciences, Tokyo, Japan aut Mori H. Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173, Tokyo, Japan aut Yoshimura M. Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173, Tokyo, Japan aut Yamanouchi H. Department of Neurology, Tokyo Geriatric Medical Centre, Tokyo, Japan aut Hayakawa K. Department of Pathology, JR Tokyo General Hospital, Tokyo, Japan aut Shimada H. Department of Pathology, Tokyo Geriatric Medical Centre, Tokyo, Japan aut Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 575-580 0001-6322 80:6<575 1990 80 401 https://doi.org/10.1007/BF00307623 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307623 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mizutani T. Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Amano N. Department of Psychiatry, Kanagawa Rehabilitation Centre, Hokkaido University, Sapporo, Japan aut NATIONALLICENCE 700 1- Sasaki H. Department of Neurology, School of Medicine, Hokkaido University, Sapporo, Japan aut NATIONALLICENCE 700 1- Morimatsu Y. Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neurosciences, Tokyo, Japan aut NATIONALLICENCE 700 1- Mori H. Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Yoshimura M. Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamanouchi H. Department of Neurology, Tokyo Geriatric Medical Centre, Tokyo, Japan aut NATIONALLICENCE 700 1- Hayakawa K. Department of Pathology, JR Tokyo General Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Shimada H. Department of Pathology, Tokyo Geriatric Medical Centre, Tokyo, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 575-580 0001-6322 80:6<575 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer