caa a22 4500 465767818 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00307632 doi (NATIONALLICENCE)springer-10.1007/BF00307632 Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases [Elektronische Daten] [W. Paulus, W. Jänisch] Summary: Sixty-seven tumor specimens of epithelial choroid plexus neoplasms obtained by 60 biopsies and 7 autopsies from 52 patients were investigated. Diagnoses of the first operations were choroid plexus papilloma (PP; 32 cases), choroid plexus papilloma with histological atypies (atypical PP; 6 cases), and choroid plexus carcinoma (PC; 14 cases). Carcinoembryonic antigen was expressed by 2 of the 3 biopsies autoptically recognized as metastatic carcinomas and by 2 autopsy cases of PC, while it was absent in all biopsies of true choroid plexus tumors. Tumor cells positive for transthyretin (TTR, prealbumin), S-100 protein (S100), and glial fibrillary acidic protein (GFAP) were detected in 39, 46 and 13, respectively, of the 49 cases of true choroid plexus tumors. Fourth ventricle tumors expressed more S100 (number of positive tumor cells) than lateral ventricle tumors, PP more S100 and TTR than atypical PP/PC. Tumors from patients 20 years of age and older expressed more GFAP and TTR than tumors from younger patients. Of the 30 patients with complete follow-up 19 were alive 2 to 11 years after surgery, including 7 recurrencies. Eleven died from the tumor 4 months to 7 years after surgery. The following histopathologic features (in order of decreasing significance) were correlated with poor prognosis (recurrency or fatal outcome): less than 50% of the tumor cells heavily positive for S100, presence of mitoses, absence of TTR-positive cells, brain invasion by cell nests, absence of marked stromal edema, and presence of necrotic areas. Our results indicate that some histologic features correlate significantly with poor prognosis and that immunohistochemical results correlate with tumor localization, age, and malignancy. Springer-Verlag, 1990 Choroid plexus papilloma nationallicence Choroid plexus carcinoma nationallicence Prognosis nationallicence Immunohistochemistry nationallicence Paulus W. Institut für Hirnforschung, Universität Tübingen, Calwer Strasse 3, D-7400, Tübingen, Federal Republic of Germany aut Jänisch W. Institut für Pathologische Anatomie, Humboldt Universität, Schumannstrasse 20/21, DDR-1040, Berlin, German Democratic Republic aut Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 635-641 0001-6322 80:6<635 1990 80 401 https://doi.org/10.1007/BF00307632 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307632 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paulus W. Institut für Hirnforschung, Universität Tübingen, Calwer Strasse 3, D-7400, Tübingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Jänisch W. Institut für Pathologische Anatomie, Humboldt Universität, Schumannstrasse 20/21, DDR-1040, Berlin, German Democratic Republic aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/6(1990-10-01), 635-641 0001-6322 80:6<635 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer