caa a22 4500 465767834 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00294649 doi (NATIONALLICENCE)springer-10.1007/BF00294649 Mandybur T. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 231 Bethesda Avenue, 45267-0533, Cincinnati, OH, USA aut The distribution of Alzheimer's neurofibrillary tangles and gliosis in chronic subacute sclerosing panencephalitis [Elektronische Daten] [T. Mandybur] Summary: In two cases of clinically verified chronic subacute sclerosing panencephalitis (case 1, male, 15 years with a 9-year history; case 2, male, 20 years with a 9-year history) numerous Alzheimer's tangles (AT) were identified throughout the cerebral cortex (containing paired helical filament on electron microsopical examination). The brains were severel atrophic with hydrocephalus ex vacuo, occasional scattered microglial nodules, scant perivascular inflammatory infiltrates and demyelination. Only in case 1 were a few atypical intranuclear inclusion bodies noted. In the six-layered neocortex, a distinct distribution pattern of AT was observed; these lesions were mainly seen in laminae II, III and V (laminar distribution). The glial fibrillary acidic protein stain displayed extensive laminar gliosis mainly of the layers I, IIa, IV and VI; layers III and V, largely occupied by the AT, remained conspicuously spared from gliosis (especially the lamina III). Gliosis was prevalent in the white matter which was atrophic and shrunk. In the hippocampus, the AT involved many pyramidal neurons and, in this layer gliosis was lighter than in the surrounding white matter. In case 2, AT were present in the nucleus of Meynert, hypothalamus and in rapha centralis of the upper brain stem. Overall, the distribution of AT resembled that seen in Alzheimer's disease and aging; however, the senile plaques, vascular amyloidosis and granulovacuolar change were totally absent in both cases. Springer-Verlag, 1990 Subacute sclerosing panencephalitis (SSPE) nationallicence Alzheimer's tangles nationallicence Gliosis nationallicence Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 307-310 0001-6322 80:3<307 1990 80 401 https://doi.org/10.1007/BF00294649 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294649 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Mandybur T. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 231 Bethesda Avenue, 45267-0533, Cincinnati, OH, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 307-310 0001-6322 80:3<307 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer