caa a22 4500 465767850 CHVBK 20180323111919.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00294638 doi (NATIONALLICENCE)springer-10.1007/BF00294638 Morphological characteristics of senile plaques in familial Alzheimer's disease [Elektronische Daten] [E. Iseki, M. Matsushita, K. Kosaka, K. Suzuki, N. Amano, A. Saito] Summary: The distribution and morphology of senile plaques (SPs) in the cerebral cortices and subcortical nuclei of six cases of familial Alzheimer's disease (AD) were examined using the Methenamine-Bodian method and compared with those of sporadic AD cases. SPs were grouped into three types according to their morphology. SP types were generally constant at each anatomical site in all of the cases. The SPs of familial cases, however, had a greater tendency to fuse together than those of sporadic cases, especially in the cingulate cortex, presubiculum and striatum. This tendency was more evident in cases with severe amyloid angiopathy. Here it appeared that a SP type corresponding to "diffuse plaques” at least in part, might be formed by transformation from another type. In the globus pallidus, all the familial cases had many compact-like plaques which appeared to be derived from "drusige Entartung” of the capillaries. Furthermore, the regional proportion of two types of SPs occuring in this nucleus varied along its anteroposterior axis. These findings may be the histological hallmarks of atypical AD rather than familial AD. Springer-Verlag, 1990 Senile plaque nationallicence Morphology nationallicence Familial Alzheimer's disease nationallicence Methenamine-Bodian method nationallicence Iseki E. Department of Psychiatry and Neurology, Yokohama City University School of Medicine, 3-46 Urafune-cho, Minami-ku, 232, Yokohama, Japan aut Matsushita M. Department of Psychiatry and Neurology, Yokohama City University School of Medicine, 3-46 Urafune-cho, Minami-ku, 232, Yokohama, Japan aut Kosaka K. Department of Neuropathology, Psychiatric Research Institute of Tokyo, 2-1-8 Kamikitazawa, Setagaya-ku, 156, Tokyo, Japan aut Suzuki K. Department of Psychiatry and Neurology, Yokohama City University School of Medicine, 3-46 Urafune-cho, Minami-ku, 232, Yokohama, Japan aut Amano N. Division of Psychiatry and Neurology, Kanagawa Rehabilitation Center, Nanasawa 516, Atsugi-shi, Kanagawa-ken, Japan aut Saito A. Serigaya-en Hospital, 2-3-1 Serigaya, Konan-ku, 233, Yokohama, Japan aut Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 227-232 0001-6322 80:3<227 1990 80 401 https://doi.org/10.1007/BF00294638 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294638 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iseki E. Department of Psychiatry and Neurology, Yokohama City University School of Medicine, 3-46 Urafune-cho, Minami-ku, 232, Yokohama, Japan aut NATIONALLICENCE 700 1- Matsushita M. Department of Psychiatry and Neurology, Yokohama City University School of Medicine, 3-46 Urafune-cho, Minami-ku, 232, Yokohama, Japan aut NATIONALLICENCE 700 1- Kosaka K. Department of Neuropathology, Psychiatric Research Institute of Tokyo, 2-1-8 Kamikitazawa, Setagaya-ku, 156, Tokyo, Japan aut NATIONALLICENCE 700 1- Suzuki K. Department of Psychiatry and Neurology, Yokohama City University School of Medicine, 3-46 Urafune-cho, Minami-ku, 232, Yokohama, Japan aut NATIONALLICENCE 700 1- Amano N. Division of Psychiatry and Neurology, Kanagawa Rehabilitation Center, Nanasawa 516, Atsugi-shi, Kanagawa-ken, Japan aut NATIONALLICENCE 700 1- Saito A. Serigaya-en Hospital, 2-3-1 Serigaya, Konan-ku, 233, Yokohama, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 227-232 0001-6322 80:3<227 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer