caa a22 4500 465767907 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00294646 doi (NATIONALLICENCE)springer-10.1007/BF00294646 Modified Bielschowsky stain and immunohistochemical studies on striatal plaques in Alzheimer's disease [Elektronische Daten] [T. Suenaga, A. Hirano, J. Llena, S. Yen, D. Dickson] Summary: The nature of senile plaques (SP) in the striatum in 14 cases of Alzheimer's disease (AD) was investigated with the modified Bielschowsky stain and immunohistochemistry using antibodies to a β amyloid synthetic peptide, ubiquitin, tau protein, and paired helical filaments (PHF). Striatal SP, composed of β amyloid deposits with or without neuritic elements, were demonstrated in all AD cases examined. Compact and perivascular amyloid deposits were concentrated in the ventral striatum, including the nucleus accumbens. Many diffuse amyloid deposis in the ventral striatum contained ubiquitin-positive granular elements, presumably representing dystrophic neurites, whereas most of those in the dorsal striatum did not have such elements. On the other hand, most compact amyloid deposits in both ventral and dorsal striatum had ubiquitin immunoreactivity. Dystrophic neurites with tau or PHF immunoreactivity were detected particularly around compact amyloid deposits. Our results indicate that the ventral striatum, which is closely affiliated with the limbic system, is frequently affected by amyloid deposits with dystrophic neurites, and suggest that the ventral striatum is particularly vulnerable to AD. Furthermore, our results suggest that amyloid deposits, especially compact deposits, may induce dystrophic neurites. Springer-Verlag, 1990 Alzheimer's disease nationallicence Senile plaque nationallicence Tau nationallicence Ubiquitin nationallicence Ventral striatum nationallicence Suenaga T. Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Hirano A. Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Llena J. Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Yen S. Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Dickson D. Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 280-286 0001-6322 80:3<280 1990 80 401 https://doi.org/10.1007/BF00294646 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294646 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suenaga T. Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Hirano A. Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Llena J. Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Yen S. Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Dickson D. Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 280-286 0001-6322 80:3<280 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer