caa a22 4500 465767915 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00294639 doi (NATIONALLICENCE)springer-10.1007/BF00294639 Ubiquitin-immunoreactive filamentous inclusions in anterior horn cells of Guamanian and non-Guamanian amyotrophic lateral sclerosis [Elektronische Daten] [S. Matsumoto, A. Hirano, S. Goto] Summary: Immunohistochemical studies with an antibody to ubiquitin revealed the presence of filamentous inclusions in spinal anterior horn cells in all of six patients with Guamanian amyotrophic lateral sclerosis (ALS) and one of six cases of parkinsonism-dementia complex (PD) on Guam. Similar ubiquitin-reactive filamentous inclusions were found in all of seven non-Guamanian sporadic ALS patients examined. No similar inclusions were seen in six normal controls or in non-ALS patients who had chromatolytic neurons. The filamentous inclusions differed from spinal neurofibrillary tangles, a characteristic feature of Guamanian ALS and PD, since they were restricted to anterior horn cells and did not react with anti-tau antibody. The chromatolytic neurons of non-ALS patients occasionally had weak diffuse immunoreactivity, but no focal inclusions were detected. These results suggest that ubiquitin-reactive focal filamentous inclusions may reflect a characteristic degenerative process of anterior horn cells of motor neuron disease. Springer-Verlag, 1990 Amyotrophic lateral sclerosis nationallicence Guam nationallicence Ubiquitin nationallicence Immunohistochemistry nationallicence Anterior horn cell nationallicence Matsumoto S. Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut Hirano A. Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut Goto S. Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 233-238 0001-6322 80:3<233 1990 80 401 https://doi.org/10.1007/BF00294639 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294639 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsumoto S. Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Hirano A. Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Goto S. Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 233-238 0001-6322 80:3<233 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer