caa a22 4500 465767923 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00294641 doi (NATIONALLICENCE)springer-10.1007/BF00294641 Loss of constitutional heterozygosity in chromosome 10 in human glioblastoma [Elektronische Daten] [K. Watanabe, M. Nagai, S. Wakai, T. Arai, K. Kawashima] Summary: Gene delection of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma (seven glioblastomas and two malignant astrocytomas) was investigated. Loss of heterozygosity was found in four of the seven (57%) cases with glioblastoma, whereas heterozygosity was preserved in two malignant astrocytome cases. One glioblastoma case showed loss of heterozygosity only in the recurring tumor tissue, although heterozygosity was maintained in the initial tumor tissue. The significance of loss of heterozygosity in the growth and recurrence of glioblastoma is discussed. Springer-Verlag, 1990 Malignant gliomas nationallicence Allelic delection nationallicence Restriction fragment length polymorphisms nationallicence Watanabe K. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan aut Nagai M. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan aut Wakai S. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan aut Arai T. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan aut Kawashima K. Biology Division, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan aut Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 251-254 0001-6322 80:3<251 1990 80 401 https://doi.org/10.1007/BF00294641 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294641 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watanabe K. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Nagai M. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Wakai S. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Arai T. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan aut NATIONALLICENCE 700 1- Kawashima K. Biology Division, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 251-254 0001-6322 80:3<251 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer