caa a22 4500 465767982 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00294648 doi (NATIONALLICENCE)springer-10.1007/BF00294648 Infantile hypertrophic pyloric stenosis: myopathic type [Elektronische Daten] [R. Dieler, J. Schröder, H. Skopnik, G. Steinau] Summary: Smooth muscle cell biopsies obtained at pyloromyotomy from 37 children with infantile hypertrophic pyloric stenosis (IHPS) were studied by light and electron microscopy and compared with 6 autopsy control cases without any clinical evidence of this disorder. In cases with IHPS an apparently irregular increase in the number of smooth muscle cells by mitosis was accompanied by an increase of the endoplasmic reticulum, proliferation of mitochondria and regressive changes, such as shrinkage, swelling, necrosis and apoptosis of smooth muscle cells. Other alterations, seen in some but not all cases consisted of large numbers of unusual dense granules some of which were clearly associated with actin filaments and, therefore, regarded as derivatives of the normally occurring dense bodies. Furthermore, intermyofibrillar and subsarcolemmal glycogen accumulations, various nuclear abnormalities and pleomorphic membranous cytoplasmic or nuclear bodies occurred. While smooth muscle cell abnormalities predominated in some cases of IHPS, in others there were more severe axonal changes in the myenteric plexus. It is suggested, therefore, that a primarily myogenic type of IHPS can be distinguished from a predominantly neurogenic type. Springer-Verlag, 1990 Pyloric stenosis nationallicence Smooth muscle nationallicence Myenteric plexus nationallicence Visceral myopathy nationallicence Neuropathy nationallicence Dieler R. Institut für Neuropathologie, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Pauwelsstrasse 30, D-5100, Aachen, Federal Republic of Germany aut Schröder J. Institut für Neuropathologie, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Pauwelsstrasse 30, D-5100, Aachen, Federal Republic of Germany aut Skopnik H. Kinderklinik, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Pauwelsstrasse 30, D-5100, Aachen, Federal Republic of Germany aut Steinau G. Chirurgische Klinik, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Pauwelsstrasse 30, D-5100, Aachen, Federal Republic of Germany aut Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 295-306 0001-6322 80:3<295 1990 80 401 https://doi.org/10.1007/BF00294648 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294648 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dieler R. Institut für Neuropathologie, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Pauwelsstrasse 30, D-5100, Aachen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schröder J. Institut für Neuropathologie, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Pauwelsstrasse 30, D-5100, Aachen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Skopnik H. Kinderklinik, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Pauwelsstrasse 30, D-5100, Aachen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Steinau G. Chirurgische Klinik, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Pauwelsstrasse 30, D-5100, Aachen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 295-306 0001-6322 80:3<295 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer