caa a22 4500 465767990 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00294647 doi (NATIONALLICENCE)springer-10.1007/BF00294647 Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation [Elektronische Daten] [T. Morimura, C. Neuchrist, K. Kitz, H. Budka, O. Scheiner, D. Kraft, H. Lassmann] Summary: Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%-30% of all cells present in the samples were recognized by various macrophage markers. These cells carried surface epitopes with known function, like Fc-γ (Fcg) and complement receptors. Microglial cells, in comparison to typical debris laden macrophages, were only recognized by a restricted panel of macrophages markers (anti-Fcg receptors 1, 2, 3, complement receptor CR3, HLA DR, common leucocyte antigen CD45 and the monocyte marker RM3/1). In peritumoral tissue mainly dendritic, microglia-like cells were present, which revealed decreased expression of antigens CD4, RM3/1 and Fcg receptors in comparison to those in gliomas. A significant positive correlation was found between the number of RM3/1 or CR3 (CD11b)-positive cells and the proliferation rate of the tumors as documented by the number of bromodeoxyuridine-positive or Ki-67+ cells. Springer-Verlag, 1990 Glioma nationallicence Macrophages nationallicence Microglia nationallicence Fc-receptors nationallicence Complement receptors nationallicence Morimura T. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Neuchrist C. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Kitz K. Neurochirurgische Klinik, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Budka H. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Scheiner O. Institut für allgemeine und experimentelle Pathologie, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Kraft D. Institut für allgemeine und experimentelle Pathologie, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Lassmann H. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 287-294 0001-6322 80:3<287 1990 80 401 https://doi.org/10.1007/BF00294647 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294647 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morimura T. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 700 1- Neuchrist C. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 700 1- Kitz K. Neurochirurgische Klinik, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 700 1- Budka H. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 700 1- Scheiner O. Institut für allgemeine und experimentelle Pathologie, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 700 1- Kraft D. Institut für allgemeine und experimentelle Pathologie, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 700 1- Lassmann H. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/3(1990-07-01), 287-294 0001-6322 80:3<287 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer