caa a22 4500 465768016 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00307700 doi (NATIONALLICENCE)springer-10.1007/BF00307700 Unmyelinated fibers in sural nerve biopsies of chronic inflammatory demyelinating polyneuropathy [Elektronische Daten] [E. Gibbels, M. Kentenich] Summary: Seven patients aged 29 to 76 years with various clinical subtypes of chronic inflammatory demyelinating polyneuropathy (CIDP) were investigated. Sural nerve biopsies were performed between 7 months and 19 years after onset of disease. Quantitative electron microscopy revealed involvement of primary unmyelinated fibers (UF) in all cases. When compared with age-matched controls from the literature and two controls of our own, there was an increase of degenerating primary UF in all cases, a definite decrease of density per mm2 or number per nerve after subtraction of regenerates of myelinated and unmyelinated fibers in five cases, an increase of denervated Schwann cell complexes of the unmyelinated type in three cases, and an increased incidence of a high ratio (≥3) of primary UF per Schwann cell complex in five cases. Presumably due to the small number and heterogeneity of cases, the results did not correlate with type and duration of CIDP, but were obviously influenced by the degree of demyelination. The possible causes of UF damage in CIDP are discussed. Springer-Verlag, 1990 Unmyelinated nerve fibers nationallicence Sural nerve biopsies nationallicence Chronic inflammatory demyelinating polyneuropathy nationallicence Gibbels E. Klinik und Poliklinik für Neurologie und Psychiatrie der Universität zu Köln, Joseph-Stelzmann-Strasse 9, D-5000, Köln 41, Federal Republic of Germany aut Kentenich M. Klinik und Poliklinik für Neurologie und Psychiatrie der Universität zu Köln, Joseph-Stelzmann-Strasse 9, D-5000, Köln 41, Federal Republic of Germany aut Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 439-447 0001-6322 80:4<439 1990 80 401 https://doi.org/10.1007/BF00307700 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307700 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gibbels E. Klinik und Poliklinik für Neurologie und Psychiatrie der Universität zu Köln, Joseph-Stelzmann-Strasse 9, D-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Kentenich M. Klinik und Poliklinik für Neurologie und Psychiatrie der Universität zu Köln, Joseph-Stelzmann-Strasse 9, D-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 439-447 0001-6322 80:4<439 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer