caa a22 4500 465768024 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00307694 doi (NATIONALLICENCE)springer-10.1007/BF00307694 Effect of denervation on regenerating muscle plasma membrane integrity: freeze-fracture and dystrophin immunostaining analyses [Elektronische Daten] [T. Jimi, Y. Wakayama] Summary: We investigated time sequentially, the densities of intramembranous assembly "orthogonal arrays” of regenerating rat extensor digitorum longus muscle after bupivacaine-induced muscle injury. There was no evidence of orthogonal arrays at the early stage, but the densities of orthogonal arrays increased with the maturation of the innervated regenerating myofibers. In contrast, the orthogonal arrays were scarcely observed at any time point examined in denervated regenerating muscles. Therefore, the neural factor may have an important effect on the appearance of orthogonal arrays. Moreover, we studied the immunostainability of Duchenne muscular dystrophy gene product "dystrophin” in the regenerating muscle at the same time points. Positive immunostaining was observed in both innervated and denervated regenerating myofibers even from the early stage of regeneration. On the basis of these data, the relationship between orthogonal array and dystrophin are discussed. Springer-Verlag, 1990 Muscle regeneration nationallicence Denervation nationallicence Dystrophin nationallicence Freeze fracture nationallicence Orthogonal array nationallicence Jimi T. Division of Neurology, Department of Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Midori-ku, 227, Yokohama, Japan aut Wakayama Y. Division of Neurology, Department of Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Midori-ku, 227, Yokohama, Japan aut Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 401-405 0001-6322 80:4<401 1990 80 401 https://doi.org/10.1007/BF00307694 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307694 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jimi T. Division of Neurology, Department of Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Midori-ku, 227, Yokohama, Japan aut NATIONALLICENCE 700 1- Wakayama Y. Division of Neurology, Department of Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Midori-ku, 227, Yokohama, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 401-405 0001-6322 80:4<401 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer