caa a22 4500 465768040 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00307691 doi (NATIONALLICENCE)springer-10.1007/BF00307691 Amyloid in the brains of aged squirrel monkeys [Elektronische Daten] [L. Walker, C. Masters, K. Beyreuther, D. Price] Summary: In this immunocytochemical study, the brains of nine squirrel monkeys (Saimiri sciureus), ranging from 8 to 27 years of age, were examined for the presence and distribution of β/A4 amyloid, a 4-kilodalton peptide. In aged squirrel monkeys, amyloid is associated primarily with intracerebral and meningeal capillaries and arterioles and occurs to a lesser degree as small and/or diffuse deposits in the neural parenchyma and in the dense cores of senile plaques. Cerebrovascular amyloid is found primarily in neocortex, amygdala, and septum verum and is rare or nonexistent in other subcortical gray structures, white matter, cerebellum, and spinal cord; this pattern of localization is comparable to that in humans with cerebral amyloid angiopathy. There is a significant correlation between cerebrovascular and parenchymal deposits of amyloid. However, cerebrovascular amyloid is always the most abundant form in squirrel monkeys, even in cases of severe cerebral amyloidosis. In contrast to squirrel monkeys, aged rhesus monkeys (Macaca mulatta) develop, mostly parenchymal deposits of amyloid and have relatively less vascular amyloid. This species difference in the histological distribution of amyloid suggests that separate mechanisms may influence the accumulation of amyloid in cerebral blood vessels and in the neural parenchyma. These data also indicate that the squirrel monkey can serve as a model for investigations of cerebrovascular amyloidosis. Springer-Verlag, 1990 β/A4 nationallicence Cerebral amyloid angiopathy nationallicence Immunocytochemistry nationallicence Salmiri sciureus nationallicence Senile plaques nationallicence Walker L. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 509 Pathology Building, 21205-2181, Baltimore, MD, USA aut Masters C. Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 509 Pathology Building, 21205-2181, Baltimore, MD, USA aut Beyreuther K. Department of Neuroscience, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 509 Pathology Building, 21205-2181, Baltimore, MD, USA aut Price D. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 509 Pathology Building, 21205-2181, Baltimore, MD, USA aut Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 381-387 0001-6322 80:4<381 1990 80 401 https://doi.org/10.1007/BF00307691 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307691 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walker L. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 509 Pathology Building, 21205-2181, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Masters C. Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 509 Pathology Building, 21205-2181, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Beyreuther K. Department of Neuroscience, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 509 Pathology Building, 21205-2181, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Price D. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 509 Pathology Building, 21205-2181, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 381-387 0001-6322 80:4<381 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer