caa a22 4500 465768059 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00307689 doi (NATIONALLICENCE)springer-10.1007/BF00307689 Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques [Elektronische Daten] [H. Yamaguchi, Y. Nakazato, M. Shoji, Y. Ihara, S. Hirai] Summary: Thread-like structures immunoreactive with paired helical filaments and tau antisera were demonstrated as mesh-works in the neocortices of five brains with Alzheimer-type dementia, but not in those of five normal aged control brains. The ultrastructure of the threads was examined using paired routine electron microscopic ultrathin sections and adjacent 0.4-μm-thick semithin sections, immunostained for β protein. Outside the β protein-positive senile plaques, neuropil threads appeared sporadically as small slender neurites, containing either regularly constricted or straight filaments. These neurites often showed dendritic profiles. Similar threads were also seen within the senile plaques. The threads were accumulated in amyloid fibril-rich primitive plaques, but not in amyloid fibril-poor diffuse plaques. The presence of these threads was closely associated with neurofibrillary tangle formation. Our findings suggest that wide-spread change of the neuropil neurites, neuropil threads or curly fibers, both outside and inside of the senile plaques are dendritic in origin and play an important role in the clinical manifestation of dementia. Springer-Verlag, 1990 Neuropil threads nationallicence Alzheimer-type dementia nationallicence tau protein nationallicence Palred helical filaments nationallicence Senile plaques nationallicence Yamaguchi H. College of Medical Care and Technology, Showa-machi, 371, Maebashi, Gunma, Japan aut Nakazato Y. Department of Pathology, School of Medicine, Gunma University, Showa-machi, 371, Maebashi, Gunma, Japan aut Shoji M. Department of Neurology, School of Medicine, Gunma University, Showa-machi, 371, Maebashi, Gunma, Japan aut Ihara Y. Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut Hirai S. Department of Neurology, School of Medicine, Gunma University, Showa-machi, 371, Maebashi, Gunma, Japan aut Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 368-374 0001-6322 80:4<368 1990 80 401 https://doi.org/10.1007/BF00307689 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307689 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamaguchi H. College of Medical Care and Technology, Showa-machi, 371, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Nakazato Y. Department of Pathology, School of Medicine, Gunma University, Showa-machi, 371, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Shoji M. Department of Neurology, School of Medicine, Gunma University, Showa-machi, 371, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Ihara Y. Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirai S. Department of Neurology, School of Medicine, Gunma University, Showa-machi, 371, Maebashi, Gunma, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 368-374 0001-6322 80:4<368 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer