caa a22 4500 465768083 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00307698 doi (NATIONALLICENCE)springer-10.1007/BF00307698 Skeletal muscle changes associated with equine myotonic dystrophy [Elektronische Daten] [G. Hegreberg, S. Reed] Summary: A progressive neuromuscular disorder in young horses, clinically apparent as early as 1 month of age, is characterized by generalized myotonia, muscle stiffness, muscle weakness and atrophy. Myotonia is identified by percussion dimpling and myotonic EMG discharges. Changes in one case included testicular hypoplasia, cataract formation, and glucose intolerance, indicating a systemic involvement. Pathologic changes in skeletal muscles from three affected foals were examined. Sarcoplasmic masses, ringed fibers, internal positioning of sarcolemmal nuclei, and nuclear rowing were among the primary histologic changes noted. Variation in fiber diameter size, especially atrophy, and type I predominance were also prominent changes. A neurogenic involvement was indicated by type grouping changes in several muscles. Springer-Verlag, 1990 Muscular dystrophy nationallicence Myotonic dystrophy nationallicence Animals nationallicence Hegreberg G. Department of Veterinary Microbiology and Pathology, Washington State University, 99164-7040, Pullman, WA, USA aut Reed S. Department of Veterinary Clinical Sciences, The Ohio State University, 43210, Columbus, OH, USA aut Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 426-431 0001-6322 80:4<426 1990 80 401 https://doi.org/10.1007/BF00307698 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307698 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hegreberg G. Department of Veterinary Microbiology and Pathology, Washington State University, 99164-7040, Pullman, WA, USA aut NATIONALLICENCE 700 1- Reed S. Department of Veterinary Clinical Sciences, The Ohio State University, 43210, Columbus, OH, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 426-431 0001-6322 80:4<426 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer