caa a22 4500 465768105 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00307697 doi (NATIONALLICENCE)springer-10.1007/BF00307697 Expression of monoamine oxidase B activity in astrocytes of senile plaques [Elektronische Daten] [S. Nakamura, T. Kawamata, I. Akiguchi, M. Kameyama, N. Nakamura, H. Kimura] Summary: Monoamine oxidase (MAO) histochemistry has been performed in brains from patients with dementia of Alzheimer type (DAT) and aged controls. Conspicuous MAO-positive cell clusters were frequently observed in the amygdala, hippocampus, and insular cortex in the brains of DAT. Double staining with glial fibrillary acidic protein immunohistochemistry revealed that the clusterforming MAO-positive cells were astrocytes. Using Bielschowsky's method, Congo red and thioflavin S counterstaining, this astrocytic mass was shown to be associated with senile plaques. By the enzyme inhibition experiment, MAO activity in senile plaques was revealed to be of type B. The present results clearly indicate that MAO-B activity is expressed in fibrillary astrocytes in or around senile plaques, suggesting that these astrocytes metabolize exogenous amines in senile plaques. Springer-Verlag, 1990 Monoamine oxidase-B nationallicence Astrocyte nationallicence Senile plaques nationallicence Dementia of Alzheimer type nationallicence Nakamura S. Department of Neurology, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan aut Kawamata T. Department of Neurology, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan aut Akiguchi I. Department of Neurology, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan aut Kameyama M. Sumitomo Hospital, 530, Osaka, Japan aut Nakamura N. Department of Internal Medicine, Yasui Hospital, 606, Kyoto, Japan aut Kimura H. Division of Molecular Neuroanatomy, Molecular Neurobiology Research Centre, Shiga University of Medical Science, 520-21, Otsu, Japan aut Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 419-425 0001-6322 80:4<419 1990 80 401 https://doi.org/10.1007/BF00307697 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307697 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakamura S. Department of Neurology, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Kawamata T. Department of Neurology, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Akiguchi I. Department of Neurology, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Kameyama M. Sumitomo Hospital, 530, Osaka, Japan aut NATIONALLICENCE 700 1- Nakamura N. Department of Internal Medicine, Yasui Hospital, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Kimura H. Division of Molecular Neuroanatomy, Molecular Neurobiology Research Centre, Shiga University of Medical Science, 520-21, Otsu, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 419-425 0001-6322 80:4<419 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer