caa a22 4500 46576813X CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00307699 doi (NATIONALLICENCE)springer-10.1007/BF00307699 The early effects of methylmercury on the developing rat brain [Elektronische Daten] [J. Geelen, J. Dormans, A. Verhoef] Summary: The effects of organic mercury compounds on the development of the brain are well known since the exposure of people at a large scale to methylmercury in the Minamata Bay area and in Iraq. The neuropathological examination of the brains of children prenatally exposed revealed dysplasia of the cerebral and cerebellar cortex, neuronal ectopia and several other developmental disturbances. In this experimental study we examined developmental mechanisms involved in methylmercury-induced cerebral anomalies. By examining the fetuses soon after treatment we concentrated in the initial effects of the treatment. The pregnant rats were given 10 mg/kg methylmercury chloride i.p. on day 18. Already at 2 h after administration mitochondrial degeneration occurred in the endothelium of the cerebral capillaries. Subsequently hemorrhages developed interfering with the cellular arrangement in the ventricular zone, with neuronal migration in the intermediate zone and with the development of the cortical cytoarchitecture. Macrophages and cavities appeared in the hemorrhagic areas. It is suggested that the abnormalities seen in the experiments can be considered as the initial methylmercury-induced effects which, in combination with various other toxic effects, ultimately result in the anomalies that have been observed in the brains of children prenatally exposed to methylmercury. Springer-Verlag, 1990 Brain nationallicence drug effects nationallicence Abnormalities, drug-induced nationallicence Pregnancy nationallicence Animals, drug effects nationallicence Methylmercury nationallicence Geelen J. Department of Teratology, National Institute of Public Health and Environmental Protection, P. O. Box 1, NL-3720 BA, Bilthoven, The Netherlands aut Dormans J. Laboratory for Pathology, National Institute of Public Health and Environmental Protection, P. O. Box 1, NL-3720 BA, Bilthoven, The Netherlands aut Verhoef A. Department of Teratology, National Institute of Public Health and Environmental Protection, P. O. Box 1, NL-3720 BA, Bilthoven, The Netherlands aut Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 432-438 0001-6322 80:4<432 1990 80 401 https://doi.org/10.1007/BF00307699 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307699 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Geelen J. Department of Teratology, National Institute of Public Health and Environmental Protection, P. O. Box 1, NL-3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Dormans J. Laboratory for Pathology, National Institute of Public Health and Environmental Protection, P. O. Box 1, NL-3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Verhoef A. Department of Teratology, National Institute of Public Health and Environmental Protection, P. O. Box 1, NL-3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 432-438 0001-6322 80:4<432 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer