caa a22 4500 465768164 CHVBK 20180323111920.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00307702 doi (NATIONALLICENCE)springer-10.1007/BF00307702 Lobar atrophy with dense-core (brain stem type) Lewy bodies in a patient with dementia [Elektronische Daten] [E. Masliah, D. Galasko, C. Wiley, L. Hansen] Summary: A 62-year-old man presented with memory impairment progressing over 6 years to dementia with near mutism and was diagnosed as having Alzheimer's disease. At autopsy his brain showed lobar atrophy suggestive of Pick's disease and there were spherical intracytoplasmic neuronal inclusions in the fascia dentata, hippocampal pyramidal cell layer, and temporal cortex. Unlike Pick bodies, however, the inclusions were eosinophilic with H&E stains, non-argyrophilic, and failed to react immunohistochemically with antibodies to paired helical filaments or Alz-50. They did label with antibodies to ubiquitin, however, and electron microscopy disclosed dense-cored granular structures with thin filamentous coronas which resembled brain stem-type Lewy bodies. The substantia nigra and locus coeruleus were not affected. Springer-Verlag, 1990 Dementia nationallicence Neuronal inclusions nationallicence Pick's disease nationallicence Lewy bodies nationallicence Immunohistochemistry nationallicence Masliah E. Department of Neurosciences, M-024, University of California, San Diego, 92093, La Jolla, CA, USA aut Galasko D. Department of Neurosciences, M-024, University of California, San Diego, 92093, La Jolla, CA, USA aut Wiley C. Department of Pathology, University of California, San Diego, 92093, La Jolla, CA, USA aut Hansen L. Department of Neurosciences, M-024, University of California, San Diego, 92093, La Jolla, CA, USA aut Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 453-458 0001-6322 80:4<453 1990 80 401 https://doi.org/10.1007/BF00307702 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00307702 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Masliah E. Department of Neurosciences, M-024, University of California, San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Galasko D. Department of Neurosciences, M-024, University of California, San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Wiley C. Department of Pathology, University of California, San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Hansen L. Department of Neurosciences, M-024, University of California, San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/4(1990-08-01), 453-458 0001-6322 80:4<453 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer