caa a22 4500 465768180 CHVBK 20180323111921.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00294604 doi (NATIONALLICENCE)springer-10.1007/BF00294604 Fibre-type composition, structure and cytoskeletal protein location of fibres in anterior tibial muscle [Elektronische Daten] Comparison between young adults and physically active aged humans [F. Jakobsson, K. Borg, L. Edström] Summary: Muscle biopsies were obtained from the anterior tibial muscle (TA) of 15 healthy, sedentary young (23-37 years) and 13 healthy and physically active elderly (66-77 years) volunteers. The mean frequency of type I fibres was lower in the young subjects compared with the elderly, but the mean type I fibre cross-sectional area was equal in the two groups. The type IIA fibres were, however, smaller in the elderly than in young subjects. Capillary density, capillary per fibre ratio, capillaries in contact with type I fibres (CC) and CC in relation to type I and type II fibre area did not differ in the two groups. The number of capillaries in contact with type IIA fibres was higher in the younger group. Only occasional and minor pathological changes were observed in the young subjects. In the elderly, such changes were much more common, including central nuclei, ring fibres, fibre splitting, scattered highly atrophic fibres, motheaten fibres and vacuoles. Ring fibres were most easily identified with anti-desmin labelling and highly atrophic fibres exhibited a rough network of labelling. Increased content of actin and spectrin was also observed at the periphery of ring fibres. In the elderly group, a qualitative ultrastructural analysis was also obtained and obvious changes included some myofilament loss, collections of lipofuscin which were also observed in satellite cells, proliferation of the SR-T systems and increased wrinkling of nuclear membranes and sarcolemma. Springer-Verlag, 1990 Anterior tibial muscle nationallicence Age nationallicence Capillary supply nationallicence Desmin nationallicence Actin nationallicence Jakobsson F. Department of Neurology, Karolinska Hospital, S-104 01, Stockholm, Sweden aut Borg K. Department of Neurology, Karolinska Hospital, S-104 01, Stockholm, Sweden aut Edström L. Department of Neurology, Karolinska Hospital, S-104 01, Stockholm, Sweden aut Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 459-468 0001-6322 80:5<459 1990 80 401 https://doi.org/10.1007/BF00294604 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294604 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jakobsson F. Department of Neurology, Karolinska Hospital, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 700 1- Borg K. Department of Neurology, Karolinska Hospital, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 700 1- Edström L. Department of Neurology, Karolinska Hospital, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 459-468 0001-6322 80:5<459 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer