caa a22 4500 465768210 CHVBK 20180323111921.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00294607 doi (NATIONALLICENCE)springer-10.1007/BF00294607 Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia [Elektronische Daten] [H. Braak, E. Braak] Summary: Cases of old-aged demented individuals exhibited abundant cortical amyloid deposits but only small numbers of neurofibrillary changes. Neuritic plaques were rare or absent. Neither Ammon's horn nor isocortex revealed sufficiently large numbers of tangles to permit the diagnosis of fully developed Alzheimer's disease. Dense accumulations of neurofibrillary tangles and neuropil threads occurred only in layer Pre-α (II) of the entorhinal region. This pattern of cortical destruction may represent a variant of Alzheimer's disease or an initial stage of this disorder. Springer-Verlag, 1990 Alzheimer's disease nationallicence Dementia nationallicence Amyloid nationallicence Neurofibrillary tangles nationallicence Entorhinal region nationallicence Braak H. Zentrum der Morphologie, Theodor Stern Kai 7, D-6000, Frankfurt/Main 70, Federal Republic of Germany aut Braak E. Zentrum der Morphologie, Theodor Stern Kai 7, D-6000, Frankfurt/Main 70, Federal Republic of Germany aut Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 479-486 0001-6322 80:5<479 1990 80 401 https://doi.org/10.1007/BF00294607 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294607 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Braak H. Zentrum der Morphologie, Theodor Stern Kai 7, D-6000, Frankfurt/Main 70, Federal Republic of Germany aut NATIONALLICENCE 700 1- Braak E. Zentrum der Morphologie, Theodor Stern Kai 7, D-6000, Frankfurt/Main 70, Federal Republic of Germany aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 479-486 0001-6322 80:5<479 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer