caa a22 4500 465768229 CHVBK 20180323111921.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00294613 doi (NATIONALLICENCE)springer-10.1007/BF00294613 Targeting of adoptively transferred experimental allergic encephalitis lesion at the sites of Wallerian degeneration [Elektronische Daten] [H. Konno, T. Yamamoto, H. Suzuki, H. Yamamoto, Y. Iwasaki, Y. Ohara, H. Terunuma, N. Harata] Summary: To clarify the implication of the major histocompatibility complex class II (Ia) antigen induction in microglia following Wallerian degeneration in the central nervous system (CNS), experimental allergic encephalitis (EAE) was adoptively transferred to Lewis rats in which Ia antigens had been induced in microglia at the sites of Wallerian degeneration. In addition to randomly distributed typical EAE lesions, the recipient rats developed distinct inflammatory lesions in accord with the distribution of Ia-positive microglia; i.e., in the ipsilateral thalamus after cortical cryoinjury, and in the ipsilateral optic nerve, the contralateral optic tract and superior colliculus after unilateral eye ball enucleation. Thus, the EAE locus may be targeted by this approach. The inflammatory response was inducible by transfer of myelin basic protein-stimulated lymphocytes but not by transfer of phytohemagglutinin-stimulated or non-stimulated lymphocytes. When examined using monoclonal antibody surface markers; OX-6 for Ia antigen, W3/13 for pan T lymphocyte and OX-8 for cytotoxic/suppresser T lymphocyte, the types of lymphocytes in these lesions did not differ from those in ordinary EAE lesions in the spinal cord. The potential role of non-immunologically induced Ia-positive cell clusters that serve as a target for autoimmune CNS diseases was discussed. Springer-Verlag, 1990 Major histocompatibility complex class II nationallicence Wallerian degeneration nationallicence Microglia nationallicence Autoimmune disease nationallicence Experimental allergic encephalitis nationallicence Konno H. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut Yamamoto T. Department of Neurology, Fukushima Medical College, Fukushima, Japan aut Suzuki H. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut Yamamoto H. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut Iwasaki Y. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut Ohara Y. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut Terunuma H. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut Harata N. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 521-526 0001-6322 80:5<521 1990 80 401 https://doi.org/10.1007/BF00294613 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294613 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Konno H. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Yamamoto T. Department of Neurology, Fukushima Medical College, Fukushima, Japan aut NATIONALLICENCE 700 1- Suzuki H. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Yamamoto H. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Iwasaki Y. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Ohara Y. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Terunuma H. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Harata N. Department of Neurological Sciences, Tohoku University School of Medicine, Seiryo Machi 1-1, 980, Sendai, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 521-526 0001-6322 80:5<521 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer