caa a22 4500 465768245 CHVBK 20180323111921.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00294609 doi (NATIONALLICENCE)springer-10.1007/BF00294609 Microglia in cerebellar plaques in Alzheimer's disease [Elektronische Daten] [L. Mattiace, P. Davies, S. Yen, D. Dickson] Summary: Cerebellar amyloid deposits in Alzheimer's disease were studied by immunocytochemistry and with a series of antibodies that recognize human microglia, including anti-HLA-DR, LN-1, Leu-M5 and leukocyte common antigen. Microglia formed a dense reticular array throughout the cerebellum in areas with and without amyloid deposits. In areas with compact and reticular amyloid deposits, microglia had morphological features consistent with activation, such as cytoplasmic swelling and shortening and thickening of cell processes. In areas with diffuse amyloid deposits, microglia had delicate and highly ramified processes. Nevertheless, microglial cells or their processes were detected in association with amyloid deposits of all morphological types. These results raise the possibility that microglia may play a fundamental role in the pathogenesis of amyloid deposition in the cerebellum in Alzheimer's disease. Springer-Verlag, 1990 Alzheimer's disease nationallicence Amyloid nationallicence HLA-DR nationallicence Microglia nationallicence Senile plaque nationallicence Mattiace L. Department of Pathology (Neuropathology), K-438, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Davies P. Department of Pathology (Neuropathology), K-438, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Yen S. Department of Pathology (Neuropathology), K-438, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Dickson D. Department of Pathology (Neuropathology), K-438, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 493-498 0001-6322 80:5<493 1990 80 401 https://doi.org/10.1007/BF00294609 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294609 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mattiace L. Department of Pathology (Neuropathology), K-438, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Davies P. Department of Pathology (Neuropathology), K-438, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Yen S. Department of Pathology (Neuropathology), K-438, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Dickson D. Department of Pathology (Neuropathology), K-438, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 493-498 0001-6322 80:5<493 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer