caa a22 4500 465768288 CHVBK 20180323111921.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00294615 doi (NATIONALLICENCE)springer-10.1007/BF00294615 The human pineal gland in aging and Alzheimer's disease: patterns of cytoskeletal antigen immunoreactivity [Elektronische Daten] [C. Pardo, L. Martin, J. Troncoso, D. Price] Summary: Patients with Alzheimer's disease (AD) and some aged controls may have diminished functions of the pineal gland. In this immunocytochemical study, we stained pineal glands from cases of AD and young and aged controls for cytoskeletal elements and amyloid. We found no evidence of neurofibrillary tangles (NFT) or the accumulation of neurofilaments, tau, A68, or β/A4 amyloid deposition in pinealocytes or associated structures in cases of AD or controls. In both AD and controls, we observed dense immunoreactivity for phosphorylated neurofilaments in marginal plexuses associated with processes of pinealocytes, boutons, and knob-like endings. The accumulation of phosphorylated neurofilaments in the processes of pinealocytes appears to be a normal morphological characteristic of the pineal gland and may not represent a pathological change. Springer-Verlag, 1990 Neurofilament nationallicence Paraneurons nationallicence Pinealocytes nationallicence Tau nationallicence Pardo C. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21205-2181, Baltimore, MD, USA aut Martin L. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21205-2181, Baltimore, MD, USA aut Troncoso J. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21205-2181, Baltimore, MD, USA aut Price D. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21205-2181, Baltimore, MD, USA aut Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 535-540 0001-6322 80:5<535 1990 80 401 https://doi.org/10.1007/BF00294615 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294615 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pardo C. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21205-2181, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Martin L. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21205-2181, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Troncoso J. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21205-2181, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Price D. Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21205-2181, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/5(1990-09-01), 535-540 0001-6322 80:5<535 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer