caa a22 4500 465768407 CHVBK 20180323111921.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00308925 doi (NATIONALLICENCE)springer-10.1007/BF00308925 Inhomogeneity of the putaminal lesion in striatonigral degeneration [Elektronische Daten] [S. Goto, A. Hirano] Summary: An immunohistochemical topographic study was carried out in the putamen from three patients with striatonigral degeneration (SND) using antibody to calcineurin (CaN), a neurochemical marker for the striatal medium-size spinous neurons. In patients with SND, there was significant depletion of CaN immunoreactivity in the putamen with the caudal and lateral portion of the putamen being consistently and severely affected. In addition, the SND patients showed an inhomogeneous distribution pattern of residual CaN staining in the putamen, where remaining CaN immunoreactivity appeared as a characteristic patchwork of "islands” resembling the "striosomes” observed by the tyrosine hydroxylase or Met-enkephalin immunostaining in the putamen from normal individuals. This finding may account for the fact that there are subregional and compartmental differences in susceptibility of the medium-sized spinous neurons in the putamen with SND. Springer-Verlag, 1990 Striatonigral degeneration nationallicence Putamen nationallicence Calcineurin nationallicence Tyrosine hydroxylase nationallicence Met-Enkephalin nationallicence Goto S. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut Hirano A. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 204-207 0001-6322 80:2<204 1990 80 401 https://doi.org/10.1007/BF00308925 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308925 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goto S. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Hirano A. Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 204-207 0001-6322 80:2<204 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer