caa a22 4500 465768415 CHVBK 20180323111921.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00308921 doi (NATIONALLICENCE)springer-10.1007/BF00308921 The neuropathology of chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat by inoculation with whole spinal cord and treatment with cyclosporin A [Elektronische Daten] [M. Pender, G. Stanley, G. Yoong, K. Nguyen] Summary: Chronic relapsing experimental allergic encephalomyelitis was induced in Lewis rats by inoculation with guinea-pig spinal cord and complete Freund's adjuvant followed by treatment with low-dose cyclosporin A. In most animals, tail and limb weakness developed in a relapsing remitting pattern but in some these signs were persistent or progressive from onset. Histological studies during the early stages of clinically active disease (< 25 days after inoculation) revealed inflammation and primary demyelination in the central nervous system (CNS), particularly the spinal cord, and in the peripheral nervous system (PNS), specifically the ventral and dorsal roots and dorsal root ganglia. Animals studied in the later stages of clinically active disease (> 28 days after inoculation) had extensive spinal cord demyelination but minimal PNS demyelination. In these animals, large plaques of demyelination with gliosis and prominent plasma cells occurred particularly in the thoracic spinal cord, and lesions of different ages were present within the spinal cord. CNS and PNS remyelination by oligodendrocytes and Schwann cells, respectively, was present in all animals studied later than 18 days after inoculation (the time of the first remission, if it occurred). In both early and late clinically active disease electron microscopy revealed macrophages invading and destroying CNS myelin sheaths. Active demyelination was sometimes found in regions of CNS remyelination, suggesting that remyelinated fibres were being attacked. Axonal degeneration occurred in the spinal cord. During clinical remission there was CNS and PNS remyelination and much less inflammation; however, active demyelination still occurred to a limited degree. Springer-Verlag, 1990 Experimental allergic encephalomyelitis nationallicence Demyelination nationallicence Cyclosporin A nationallicence Lewis rat nationallicence Multiple sclerosis nationallicence Pender M. Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia aut Stanley G. Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia aut Yoong G. Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia aut Nguyen K. Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia aut Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 172-183 0001-6322 80:2<172 1990 80 401 https://doi.org/10.1007/BF00308921 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308921 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pender M. Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia aut NATIONALLICENCE 700 1- Stanley G. Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia aut NATIONALLICENCE 700 1- Yoong G. Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia aut NATIONALLICENCE 700 1- Nguyen K. Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 172-183 0001-6322 80:2<172 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer