caa a22 4500 465768482 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00308919 doi (NATIONALLICENCE)springer-10.1007/BF00308919 Argyrophilic nucleolar organizer region proteins (Ag-NORs) in human brain tumors: relations with grade of malignany and proliferation indices [Elektronische Daten] [H. Maier, T. Morimura, D. Öfner, C. Hallbrucker, K. Kitz, H. Budka] Summary: Proliferation indices and mean number of silver-stained nucleolar organizer region-associated proteins (Ag-NORs) are compared in 65 brain tumors, including 34 gliomas, 8 meningiomas, 17 metastatic tumors, and 6 other tumors. Immunocytochemical investigations include labeling with the monoclonal antibody Ki-67 which identifies the whole growth fraction, and with a monoclonal antibody against bromodeoxyuridine (BrdUrd) which detects cells in the S phase of the cell cycle after in vitro incubation with BrdUrd. When all types of tumors are collectively considered, mean numbers of Ag-NORs did not correlate with Ki-67 and Brd-Urd labeling indices (LIs) and mitotic index. Among tumor subtypes, only meningiomas showed significant correlations between Ag-NOR counts, LIs, and malignancy. Mean number of Ag-NORs did not correlate with proliferation indices and tumor grade in low-grade and high-grade gliomas. However, recurrent high-grade gliomas showed a tendency to higher Ag-NOR counts than primary tumors. This study indicates that counting of Ag-NORs in paraffin sections is of limited value in tumor neuropathology. Correlations found in meningeal tumors should be substantiated in larger series. Springer-Verlag, 1990 Cell kinetics nationallicence Cell cycle nationallicence Brain tumor nationallicence Cell proliferation nationallicence Nucleolar organizer region proteins nationallicence Maier H. Pathologisches Institut, Universität Innsbruck, Austria aut Morimura T. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Öfner D. Abteilung für Chirurgie I, Universität Innsbruck, Austria aut Hallbrucker C. Pathologisches Institut, Universität Innsbruck, Austria aut Kitz K. Neurochirurgische Klinik, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Astria aut Budka H. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 156-162 0001-6322 80:2<156 1990 80 401 https://doi.org/10.1007/BF00308919 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308919 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maier H. Pathologisches Institut, Universität Innsbruck, Austria aut NATIONALLICENCE 700 1- Morimura T. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 700 1- Öfner D. Abteilung für Chirurgie I, Universität Innsbruck, Austria aut NATIONALLICENCE 700 1- Hallbrucker C. Pathologisches Institut, Universität Innsbruck, Austria aut NATIONALLICENCE 700 1- Kitz K. Neurochirurgische Klinik, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Astria aut NATIONALLICENCE 700 1- Budka H. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 156-162 0001-6322 80:2<156 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer