caa a22 4500 465768504 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00308922 doi (NATIONALLICENCE)springer-10.1007/BF00308922 Ludwin S. Department of Pathology, Kingston General Hospital, K7L 3N6, Kingston, Ontario, Canada aut Oligodendrocyte survival in Wallerian degeneration [Elektronische Daten] [S. Ludwin] Summary: The long-term survival of oligodendrocytes in the absence of axons in adult animals was studied following Wallerian degeneration of the optic nerves of adult rats for periods up to 22 months. In contrast to the findings in development and in young animals, large numbers of oligodendrocytes survived during this time period even when deprived of axonal stimuli. The morphological phenotype of many of these cells differed from those of normal oligodendrocytes, and their oligodendrocytic nature was confirmed at a light microscopic level using antibodies to carbonic anhydrase, and at an electron microscopic level by using antibodies to myelin oligodendrocyte glycoprotein. Although there did appear to be some loss of oligodendrocytes over time, a large proportion appeared to remain intact. Many of the remaining cells and processes appeared to resemble resting or quiescent cells. The survival of these cells demonstrates the differential susceptibility of mature and developing oligodendrocytes to loss of axonal stimulus and also indicates a possible reserve capacity for repair following central nervous system injury. Springer-Verlag, 1990 Wallerian degeneration nationallicence Oligodendrocytes nationallicence Axons nationallicence Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 184-191 0001-6322 80:2<184 1990 80 401 https://doi.org/10.1007/BF00308922 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308922 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ludwin S. Department of Pathology, Kingston General Hospital, K7L 3N6, Kingston, Ontario, Canada aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 184-191 0001-6322 80:2<184 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer