caa a22 4500 465768520 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00308927 doi (NATIONALLICENCE)springer-10.1007/BF00308927 Correlation between microscopical changes and Tau 64 and 69 biochemical detection in senile dementia of the Alzheimer type [Elektronische Daten] Tau 64 and 69 are reliable markers of the neurofibrillary degeneration [S. Flament, A. Delacourte, P. Delaère, C. Duyckaerts, J.-J. Hauw] Summary: We have recently reported that the immunoblot detection of two abnormally phosphorylated tau proteins, named Tau 64 and 69, in homogenates of cortical areas from patients with Alzheimer's disease (AD) was systematically associated with the presence of neurofibrillary tangles (NFT) and senile plaques (SP) in these areas. A blind study was performed to confirm that these proteins had a reliable diagnostic value and to study more precisely the correlation between Tau 64 and 69 and the presence of the characteristic lesions of AD. The density of NFT and of SP was evaluated on histological sections of gyrus supramarginalis from 17 patients with graded intellectual status. Immunodetection of Tau 64 and 69 was semiquantitatively evaluated by densitometry (reflectance mode) on immunoblots of homogenates of the same area on the contralateral hemisphere. The statistical analysis of results showed that Tau 64 and 69 were more strongly correlated with NFT than with SP. Moreover, semiquantitative evaluation of Tau 64 and 69 was correlated with the intellectual status (BTS score). Therefore, these pathological forms of tau proteins are reliable markers of the presence of NFT and SP in the neocortex and may be used as a diagnostic tool. Springer-Verlag, 1990 Alzheimer's disease nationallicence Tau proteins nationallicence Phosphorylation nationallicence neurofibrillary degeneration nationallicence Flament S. Laboratoire de Neurosciences, U16 INSERM, Faculté de Médecine, F-59045, Lille, France aut Delacourte A. Laboratoire de Neurosciences, U16 INSERM, Faculté de Médecine, F-59045, Lille, France aut Delaère P. Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpétrière, 47, Blvd de l'Hôpital, F-75651, Paris Cedex 13, France aut Duyckaerts C. Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpétrière, 47, Blvd de l'Hôpital, F-75651, Paris Cedex 13, France aut Hauw J.-J Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpétrière, 47, Blvd de l'Hôpital, F-75651, Paris Cedex 13, France aut Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 212-215 0001-6322 80:2<212 1990 80 401 https://doi.org/10.1007/BF00308927 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308927 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Flament S. Laboratoire de Neurosciences, U16 INSERM, Faculté de Médecine, F-59045, Lille, France aut NATIONALLICENCE 700 1- Delacourte A. Laboratoire de Neurosciences, U16 INSERM, Faculté de Médecine, F-59045, Lille, France aut NATIONALLICENCE 700 1- Delaère P. Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpétrière, 47, Blvd de l'Hôpital, F-75651, Paris Cedex 13, France aut NATIONALLICENCE 700 1- Duyckaerts C. Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpétrière, 47, Blvd de l'Hôpital, F-75651, Paris Cedex 13, France aut NATIONALLICENCE 700 1- Hauw J.-J Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpétrière, 47, Blvd de l'Hôpital, F-75651, Paris Cedex 13, France aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 212-215 0001-6322 80:2<212 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer