caa a22 4500 465768547 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00308923 doi (NATIONALLICENCE)springer-10.1007/BF00308923 Experimental glycerol myopathy: a histological study [Elektronische Daten] [H. Kawai, H. Nishino, K. Kusaka, T. Naruo, Y. Tamaki, M. Iwasa] Summary: Histopathological changes induced by the intramuscular injection of glycerol were studied in the muscle fibers of rabbits. Fifteen minutes after the injection of 1 ml of 50% (v/v) glycerol, hypercontraction of fibers, disruption of the plasma membrane, and invasion of lanthanum into the sarcoplasm were observed. Between 12 and 24 h after the injection, more extensive pathological changes were seen which included: variation in fiber size; degeneration and necrosis of muscle fibers; hypercontraction of fibers by light microscopy; disruption of the plasma membrane by electron microscopy; vacuolar changes; hypercontraction of myofibrils, and selective loss of Z-bands. Between 7 and 14 days after glycerol injection, extensive regenerative changes were seen. The degenerative changes were similar to those seen in muscle in Duchenne muscular dystrophy, suggesting that a similar mechanism may be involved in the two conditions, so that experimental glycerol myopathy could be a good model for pathophysiological studies on Duchenne muscular dystrophy. Springer-Verlag, 1996 Glycerol nationallicence Experimental myopathy nationallicence Muscle pathology nationallicence Duchenne muscular dystrophy nationallicence Opaque fiber nationallicence Kawai H. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut Nishino H. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut Kusaka K. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut Naruo T. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut Tamaki Y. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut Iwasa M. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 192-197 0001-6322 80:2<192 1990 80 401 https://doi.org/10.1007/BF00308923 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308923 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawai H. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Nishino H. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Kusaka K. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Naruo T. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Tamaki Y. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Iwasa M. First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3, 770, Tokushima, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 80/2(1990-06-01), 192-197 0001-6322 80:2<192 1990 80 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer