caa a22 4500 465768571 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00662634 doi (NATIONALLICENCE)springer-10.1007/BF00662634 Cytochrome c oxidase and coenzyme Q in neuromuscular diseases: a histochemical study [Elektronische Daten] [C. Doriguzzi, L. Palmucci, B. Pollo, T. Mongini, M. Maniscalco, L. Chiadò-Piat, D. Schiffer] Summary: Cytochromec oxidase (CCO) has been histochemically studied in 250 muscle biopsies from patients with different neuromuscular diseases. The results were compared with those obtained on serial sections stained with Gomori's trichrome and with the methods for NADH tetrazolium reductase, succinate dehydrogenase and lactate dehydrogenase. In 58 selected cases serial sections were also stained with a method demonstrating coenzyme Q (CoQ) activity. Demonstration of structural alterations was as good with CCO as with the methods for other oxidative enzymes: particularly evident were alterations of the distribution of mitochondria, such as core areas in central core and multiminicore diseases. Unstained fibers were observed in mitochondrial myopathies, in Becker, Emery-Dreifuss, limb-girdle, facio-scapulo-humeral muscular dystrophies, muscle infarction, polymyositis, motor neuron diseases and neuropathies. The histochemical method for CoQ showed only low specificity, since partial staining was also present in areas devoid of mitochondria, such as cores. CoQ deficiency was not observed in any of the 19 mitochondrial myopathies examined. Springer-Verlag, 1990 Cytochrome c oxidase nationallicence Coenzyme Q nationallicence Muscle biopsy nationallicence Hystochemistry nationallicence Doriguzzi C. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut Palmucci L. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut Pollo B. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut Mongini T. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut Maniscalco M. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut Chiadò-Piat L. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut Schiffer D. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 25-29 0001-6322 81:1<25 1990 81 401 https://doi.org/10.1007/BF00662634 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00662634 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Doriguzzi C. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut NATIONALLICENCE 700 1- Palmucci L. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut NATIONALLICENCE 700 1- Pollo B. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut NATIONALLICENCE 700 1- Mongini T. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut NATIONALLICENCE 700 1- Maniscalco M. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut NATIONALLICENCE 700 1- Chiadò-Piat L. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut NATIONALLICENCE 700 1- Schiffer D. Centro per le Malattie Neuromuscolari Paolo Peirolo, Clinica Neurologica II, Università di Torino, via Cherasco 15, I-10126, Torino, Italy aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 25-29 0001-6322 81:1<25 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer