caa a22 4500 465768598 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00662636 doi (NATIONALLICENCE)springer-10.1007/BF00662636 Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease [Elektronische Daten] [U. Deschl, L. Stitz, S. Herzog, K. Frese, R. Rott] Summary: After intracerebral infection with Borna disease virus adult Lewis rats develop a virus-induced immunopathological reaction resulting in severe neurological symptoms and a non-purulent meningoencephalitis. The composition of inflammatory cells and major histocompatibility complex (MHC) class II antigen expression during the course of the infection was investigated using immunocytochemistry with a panel of monoclonal antibodies (mAb). Macrophages and lymphocytes of the T helper phenotype (CD4+) were dominant at all stages of infection, whereas T suppressor/cytotoxic lymphocytes (CD8+) were less frequent. B lymphocytes and plasma cells occurred mainly during later stages of the disease and marked parenchymal deposition of immunoglobulin developed. Beginning 10 days after infection massive expression of MHC class II antigen was noted up to the termination of experiments 70 days after infection. Besides lymphatic cells and macrophages, cells morphologically resembling microglia expressed this antigen. Furthermore, ependymal cells were found positive for MHC class II expression during infection whereas astrocytes remained negative. These findings are consistent with previous results which provide evidence for a delayed-type hypersensitivity reaction being operative in the pathogenesis of Borna disease. Springer-Verlag, 1990 Borna disease nationallicence Meningoencephalitis nationallicence Inflammatory cells nationallicence Major histocompatibility complex nationallicence Class II antigen nationallicence Immunocytochemistry nationallicence Deschl U. Institut für Veterinär-Pathologie, Frankfurter Strasse 96, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut Stitz L. Institut für Virologie, Frankfurter Strasse 107, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut Herzog S. Institut für Virologie, Frankfurter Strasse 107, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut Frese K. Institut für Veterinär-Pathologie, Frankfurter Strasse 96, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut Rott R. Institut für Virologie, Frankfurter Strasse 107, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 41-50 0001-6322 81:1<41 1990 81 401 https://doi.org/10.1007/BF00662636 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00662636 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Deschl U. Institut für Veterinär-Pathologie, Frankfurter Strasse 96, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Stitz L. Institut für Virologie, Frankfurter Strasse 107, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Herzog S. Institut für Virologie, Frankfurter Strasse 107, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Frese K. Institut für Veterinär-Pathologie, Frankfurter Strasse 96, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Rott R. Institut für Virologie, Frankfurter Strasse 107, Justus-Liebig-Universität Giessen, D-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 41-50 0001-6322 81:1<41 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer