caa a22 4500 465768636 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00662641 doi (NATIONALLICENCE)springer-10.1007/BF00662641 Demyelination and remyelination in spinal cord lesions of human lymphotropic virus type I-associated myelopathy [Elektronische Daten] [E. Ohama, Y. Horikawa, T. Shimizu, T. Morita, K. Nemoto, H. Tanaka, F. Ikuta] Summary: We describe postmortem findings in a patient with human T lymphotropic virus type I (HTLV-I)-as-sociated myelopathy (HAM). The patient developed the disease 8 years after blood transfusion and showed good response to corticosteroid treatment but died of cardiac failure. Histologically, chronic, mild meningoence-phalomyelitis was noted predominantly involving the bilateral lateral and anterior columns of the middle to lower thoracic segments. The spinal cord lesions showed obvious loss of myelinated nerve fibers and fibrillary gliosis with minimal inflammatory cell infiltration. Electron microscopy of the lesion revealed disintegration of the myelin sheaths, regular separation of the minor dense line of the myelin sheaths, and completely demyelinated axons. In addition, remyelinated fibers with thin central myelin sheaths and disproportionately large axons were seen frequently. These findings indicate that primary demyelination and remyelination by oligodendrocytes occur in the spinal cord lesions of HAM. Springer-Verlag, 1990 HTLV-I-associated myelopathy nationallicence Spinal cord lesion nationallicence Electron microscopy nationallicence Primary demyelination nationallicence Remyelination by oligodendrocytes nationallicence Ohama E. Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, 951, Niigata, Japan aut Horikawa Y. Department of Neurology, Shinrakuen Hospital, 1 Nishiariakecho, 950-21, Niigata, Japan aut Shimizu T. Department of Surgery, Shinrakuen Hospital, 1 Nishiariakecho, 950-21, Niigata, Japan aut Morita T. Department of Pathology, Shinrakuen Hospital, 1 Nishiariakecho, 950-21, Niigata, Japan aut Nemoto K. Department of Pathology, School of Medicine, Niigata University, Asahimachi, 951, Niigata, Japan aut Tanaka H. Department of Neurology, Shinrakuen Hospital, 1 Nishiariakecho, 950-21, Niigata, Japan aut Ikuta F. Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, 951, Niigata, Japan aut Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 78-83 0001-6322 81:1<78 1990 81 401 https://doi.org/10.1007/BF00662641 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00662641 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohama E. Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Horikawa Y. Department of Neurology, Shinrakuen Hospital, 1 Nishiariakecho, 950-21, Niigata, Japan aut NATIONALLICENCE 700 1- Shimizu T. Department of Surgery, Shinrakuen Hospital, 1 Nishiariakecho, 950-21, Niigata, Japan aut NATIONALLICENCE 700 1- Morita T. Department of Pathology, Shinrakuen Hospital, 1 Nishiariakecho, 950-21, Niigata, Japan aut NATIONALLICENCE 700 1- Nemoto K. Department of Pathology, School of Medicine, Niigata University, Asahimachi, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Tanaka H. Department of Neurology, Shinrakuen Hospital, 1 Nishiariakecho, 950-21, Niigata, Japan aut NATIONALLICENCE 700 1- Ikuta F. Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, 951, Niigata, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 78-83 0001-6322 81:1<78 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer