caa a22 4500 465768644 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00662645 doi (NATIONALLICENCE)springer-10.1007/BF00662645 Cytomegalovirus (CMV) encephalomyeloradiculitis and human immunodeficiency virus (HIV) encephalitis: presence of HIV and CMV co-infected multinucleated giant cells [Elektronische Daten] [L. Bélec, F. Gray, J. Mikol, F. Scaravilli, C. Mhiri, A. Sobel, J. Poirier] Summary: A 25-year-old homosexual male with AIDS presented with a cauda equina syndrome clinically suggestive of cytomegalovirus (CMV) myeloradiculitis. He was treated with ganciclovir with transient improvement of neurological signs and died 4 months after onset of neurological signs. Neuropathological examination revealed human immunodeficiency virus (HIV) encephalitis, CMV subependymal encephalitis and CMV myeloradiculitis. The latter was characterised by myelin loss, Schwann cell proliferation and presence of CMV early antigens in the nuclei of S-100 protein-positive cells in the spinal roots. In the subependymal regions, morphologically characteristic multinucleated giant cells, positive for CD68, contained early CMV antigens (E13) in their nuclei and HIV antigens (gp41 and p24) in their cytoplasm. The observation that HIV and CMV can co-infect the same cell in vivo raises the possibility of a direct synergistic interaction of both viruses at cell level. This suggests that CMV may play a role as a co-factor in the pathogenesis of HIV encephalopathy. Springer-Verlag, 1990 Human immunodeficiency virus nationallicence Cytomegalovirus nationallicence Acquired immune deficiency syndrome nationallicence Mulunucleated giant cell nationallicence Bélec L. Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut Gray F. Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut Mikol J. Laboratoire Central d'Anatomie et de Cytologie Pathologiques, Hôpital Lariboisière, Paris, France aut Scaravilli F. Department of Neuropathology, Institute of Neurology, Queen Square, London, UK aut Mhiri C. Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut Sobel A. Département d'Immunologie Clinique, Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut Poirier J. Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 99-104 0001-6322 81:1<99 1990 81 401 https://doi.org/10.1007/BF00662645 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00662645 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bélec L. Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut NATIONALLICENCE 700 1- Gray F. Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut NATIONALLICENCE 700 1- Mikol J. Laboratoire Central d'Anatomie et de Cytologie Pathologiques, Hôpital Lariboisière, Paris, France aut NATIONALLICENCE 700 1- Scaravilli F. Department of Neuropathology, Institute of Neurology, Queen Square, London, UK aut NATIONALLICENCE 700 1- Mhiri C. Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut NATIONALLICENCE 700 1- Sobel A. Département d'Immunologie Clinique, Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut NATIONALLICENCE 700 1- Poirier J. Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, F-94010, Créteil Cedex, France aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 99-104 0001-6322 81:1<99 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer