caa a22 4500 465768652 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00662631 doi (NATIONALLICENCE)springer-10.1007/BF00662631 Spinal neuronal pathology associated with continuous intrathecal infusion of N -methyl- d -aspartate in the rat [Elektronische Daten] [S. Nag, R. Riopelle] Summary: Continuous intrathecal infusion ofN-methyl-d-aspartate (NMDA) at the level of the lumbar enlargement of the spinal cord in middle-aged rats produced dose-dependent toxicity of spinal cord neuronal systems. Toxicity was enhanced by coadministration of glycine, but was significantly reduced when NMDA was coadministered with the competitive inhibitordl-2-amino-5-phosphovaleric acid or the noncompetitive inhibitor MgSO4. The toxic effects of NMDA were manifest most dramatically and at the lowest concentrations in the neuropil, while neuronal loss was obvious at higher concentrations. The distribution and intensity of reactive astrocytosis was consistent with the known regional and subcellular distribution of NMDA receptors in the spinal cord of rats. The increase in ribosomes and rough endoplasmic reticulum observed in anterior horn cells suggested an increase of cell metabolism reflecting either a nonspecific response to injury or a specific increase in cell metabolism secondary to sustained activation of NMDA receptors. The present studies implicate excitatory amino acid receptors of the NMDA type in producing toxicity to selected neuronal populations of the spinal cord. This model provides a system for studies of the protective effects and rescue of neuronal populations susceptible to the toxic effects of excitatory amino acids. Springer-Verlag, 1990 N -Methyl- d -aspartate nationallicence Spinal cord nationallicence Excitatory amino acid nationallicence Anterior horn cells nationallicence Nag S. Department of Pathology (Neuropathology), Queen's University, K7L 3N6, Kingston, Ontario, Canada aut Riopelle R. Department of Medicine (Neurology), Queen's University, K7L 3N6, Kingston, Ontario, Canada aut Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 7-13 0001-6322 81:1<7 1990 81 401 https://doi.org/10.1007/BF00662631 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00662631 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nag S. Department of Pathology (Neuropathology), Queen's University, K7L 3N6, Kingston, Ontario, Canada aut NATIONALLICENCE 700 1- Riopelle R. Department of Medicine (Neurology), Queen's University, K7L 3N6, Kingston, Ontario, Canada aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 7-13 0001-6322 81:1<7 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer