caa a22 4500 465768660 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00662638 doi (NATIONALLICENCE)springer-10.1007/BF00662638 The cytoarchitectonic distribution of senile plaques in three aged monkeys [Elektronische Daten] [P. Heilbroner, T. Kemper] Summary: The density of senile plaques (SP) was determined in 55 cytoarchitectonic areas of the cerebral cortex in three aged (27 + years) macaque monkeys. In silverstained sections the SP distributions pattern was variable, with a predilection for frontal areas and the primary somatosensory cortex. In one monkey, SP density in motor and premotor areas reached a level comparable to that found in Alzheimer's disease (AD). Lower SP densities were found in the amygdala and insula, and in cingulate, limbic temporal, and temporal, occipital, and parietal association cortices. Then lowest densities were in the hippocampus and in the primary auditory and primary visual cortices. SP stained with Congo red, to identify the older amyloid-containing plaques, showed a similar distribution.but were fewer in number. There was at times a marked shift in SP density between adjacent cytoarchitectonic fields, suggesting that cytoarchitectonics or connectivity may play a role in determining SP distribution. The distribution of the SP in the normal aged human brain according to cytoarchitectonic areas is not known. Their pattern of distribution in these three primates appears to differ from that found in AD, which emphasizes the hippocampus, amygdala, entorhinal cortex, and temporal and parietal lobe. Springer-Verlag, 1990 Senile plaque nationallicence Cytoarchitectonics nationallicence Aging nationallicence Nonhuman primate nationallicence Heilbroner P. Department of Anatomy, Boston University School of Medicine, Boston, USA aut Kemper T. Department of Anatomy, Boston University School of Medicine, Boston, USA aut Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 60-65 0001-6322 81:1<60 1990 81 401 https://doi.org/10.1007/BF00662638 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00662638 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Heilbroner P. Department of Anatomy, Boston University School of Medicine, Boston, USA aut NATIONALLICENCE 700 1- Kemper T. Department of Anatomy, Boston University School of Medicine, Boston, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 60-65 0001-6322 81:1<60 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer