caa a22 4500 465768679 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00662633 doi (NATIONALLICENCE)springer-10.1007/BF00662633 Distribution of nerve lesions in serotonin-induced acute ischemic neuropathy [Elektronische Daten] [J. Korthals, M. Korthals] Summary: We have developed a new model of an acute ischemic nerve injury in rat produced by the combined effects of right femoral artery ligation and intraperitoneal injection of serotonin. Light microscopic studies were performed on the right sciatic, tibial, plantar and sural nerves dissected from rats 7 days to 6 months after serotonin injection. Ischemic lesions occurred mostly in the middle tibial nerve and involved either a part or the whole transverse nerve section. Partial tibial nerve lesions appeared mainly as small subperineurial or large wedge-shaped areas of fiber loss or regeneration. No well-deiineated central fascicular lesions were seen. Sural nerves were less damaged than tibial nerves. The predominantly subperineurial fascicular distribution of ischemic lesions seen in the present model differs from the central fascicular distribution found in previous experimental studies on nerve ischemia. The different distribution of lesions is probably related to the small fascicular size and local microvascular architecture of the affected nerve segment, as well as to the method of producing ischemia. Springer-Verlag, 1990 Nerve nationallicence Ischemia nationallicence Serotonin nationallicence Korthals J. James A. Haley Veterans Hospital, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Box 55, 33612, Tampa, FL, USA aut Korthals M. James A. Haley Veterans Hospital, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Box 55, 33612, Tampa, FL, USA aut Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 20-24 0001-6322 81:1<20 1990 81 401 https://doi.org/10.1007/BF00662633 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00662633 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Korthals J. James A. Haley Veterans Hospital, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Box 55, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Korthals M. James A. Haley Veterans Hospital, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Box 55, 33612, Tampa, FL, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 20-24 0001-6322 81:1<20 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer