caa a22 4500 465768687 CHVBK 20180323111922.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00662637 doi (NATIONALLICENCE)springer-10.1007/BF00662637 The involvement of the cerebral cortex in human immunodeficiency virus encephalopathy: a morphological and immunohistochemical study [Elektronische Daten] [A. Ciardi, E. Sinclair, F. Scaravilli, N. Harcourt-Webster, S. Lucas] Summary: The encephalopathy resulting from direct infection of the brain by human immunodeficiency virus (HIV), which correlates clinically with the AIDS dementia complex, has been reported as being localized to the white matter where it induces myelin loss, gliosis and perivascular infiltration by mononuclear macrophages and multinucleated giant cells. Damage to the cortical grey matter in HIV encephalopathy was investigated in nine randomly selected HIV-positive cases with or without clinical or morphological evidence of encephalopathy and in five age-matched controls, using routine histology and immunohistochemical methods [glial fibrillary acidic protein (GFAP), microglia and HIV antibodies]. Increased numbers of GFAP-expressing astrocytes andRicinus communis agglutinin 1-120-expressing microglial cells were found in all the HIV-positive cases (including asymptomatic) and their severity could be correlated with the severity of the encephalopathy in the white matter: the increase in number of cells expressing GFAP was diffuse and the intensity of the staining higher than that of microglial cells. The subpial region was the most severely involved. It is suggested that involvement of the cortical grey matter is more common in HIV infection than previously suspected and that clinical evidence of a dementing process in AIDS is not necessarily due only to white matter lesions. Springer-Verlag, 1990 AIDS nationallicence HIV encephalopathy nationallicence Immunohistochemistry nationallicence Cortex nationallicence Ciardi A. Department of Neuropathology, Institute of Neurology, The National Hospital, Queen Square, WC1, London, UK aut Sinclair E. Department of Neuropathology, Institute of Neurology, The National Hospital, Queen Square, WC1, London, UK aut Scaravilli F. Department of Neuropathology, Institute of Neurology, The National Hospital, Queen Square, WC1, London, UK aut Harcourt-Webster N. Department of Pathology, Westminster Hospital, London, UK aut Lucas S. Department of Histopathology, University College and Middlesex Hospital, London, UK aut Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 51-59 0001-6322 81:1<51 1990 81 401 https://doi.org/10.1007/BF00662637 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00662637 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ciardi A. Department of Neuropathology, Institute of Neurology, The National Hospital, Queen Square, WC1, London, UK aut NATIONALLICENCE 700 1- Sinclair E. Department of Neuropathology, Institute of Neurology, The National Hospital, Queen Square, WC1, London, UK aut NATIONALLICENCE 700 1- Scaravilli F. Department of Neuropathology, Institute of Neurology, The National Hospital, Queen Square, WC1, London, UK aut NATIONALLICENCE 700 1- Harcourt-Webster N. Department of Pathology, Westminster Hospital, London, UK aut NATIONALLICENCE 700 1- Lucas S. Department of Histopathology, University College and Middlesex Hospital, London, UK aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/1(1990-01-01), 51-59 0001-6322 81:1<51 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer