caa a22 4500 465768768 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00334498 doi (NATIONALLICENCE)springer-10.1007/BF00334498 Curly fibers are tau-positive strands in the pre- and post-synaptic neurites, consisting of paired helical filaments: observations by the freeze-etch and replica method [Elektronische Daten] [K. Ohtsubo, N. Izumiyama, S. Kuzuhara, H. Mori, H. Shimada] Summary: The ultrastructure of the curly fibers was examined by the transmission and immunoelectron microscopy as well as by the rapid-freeze, deep-etch and replica method. The curly fibers consisted mainly of paired helical filaments (PHF) in the neuropils, both pre- and post-synaptic. On the deep-etch replicas, PHF in the neurites had similar dimensions to those of Alzheimer's neurofibrillary tangles in the nerve cell somata, having the width of 28 to 36 nm. The two component filaments, 14 to 18 nm in width, were twisted left-handedly with about 70- to 90-nm intervals. There were also cross-bridging fibrils of about 6 nm in diameter connecting the neighboring PHF. Springer-Verlag, 1990 Curly fibers nationallicence Anti-tau antibody nationallicence Immunoelectron microscopy nationallicence Rapid-freeze and deep-etch method nationallicence Neuritic paired helical filaments nationallicence Ohtsubo K. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashiku, 173, Tokyo, Japan aut Izumiyama N. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashiku, 173, Tokyo, Japan aut Kuzuhara S. Department of Neurology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Mori H. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashiku, 173, Tokyo, Japan aut Shimada H. Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 111-115 0001-6322 81:2<111 1990 81 401 https://doi.org/10.1007/BF00334498 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00334498 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohtsubo K. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Izumiyama N. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Kuzuhara S. Department of Neurology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Mori H. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Shimada H. Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 111-115 0001-6322 81:2<111 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer