caa a22 4500 465768806 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00334510 doi (NATIONALLICENCE)springer-10.1007/BF00334510 Alzheimer's neurofibrillary tangles and paired helical filaments in the pheochromocytoma cells of the adrenal medulla —Electron microscopic and immunoelectron microscopic observations [Elektronische Daten] [N. Izumiyama, E. Asami, Y. Itoh, K. Ohtsubo] Summary: Alzheimer's neurofibrillary tangles (NFT) and paired helical filaments (PHF) were found in the pheochromocytoma cells of the adrenal gland removed from a 54-year-old female. By electron microscopy they were identical to those found in the brains affected by dementia of Alzheimer type. In the tumor cells, most of the PHF were found dispersed loosely in the cytoplasm, while typical NFT were infrequent. By immunoelectron microscopy using peroxidase-antiperoxidase method, both NFT and dispersed PHF were stained positively with a polyclonal antiserum to human tau protein. This is the first observation of NFT and PHF in paraneuronal tumor cells. The patient has no obvious Alzheimer's disease. Springer-Verlag, 1990 Alzheimer's neurofibrillary tangles nationallicence Paired helical filaments nationallicence Adrenal pheochromocytoma nationallicence Antitau antibody nationallicence Immunoelectron microscopy nationallicence Izumiyama N. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Asami E. Department of Clinical Pathology, Tokyo Metropolitan Tama Geriatric Hospital, 7-1, Aobacho-1, Higashimurayama, 189, Tokyo, Japan aut Itoh Y. Department of Clinical Pathology, Tokyo Metropolitan Tama Geriatric Hospital, 7-1, Aobacho-1, Higashimurayama, 189, Tokyo, Japan aut Ohtsubo K. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 213-216 0001-6322 81:2<213 1990 81 401 https://doi.org/10.1007/BF00334510 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00334510 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Izumiyama N. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Asami E. Department of Clinical Pathology, Tokyo Metropolitan Tama Geriatric Hospital, 7-1, Aobacho-1, Higashimurayama, 189, Tokyo, Japan aut NATIONALLICENCE 700 1- Itoh Y. Department of Clinical Pathology, Tokyo Metropolitan Tama Geriatric Hospital, 7-1, Aobacho-1, Higashimurayama, 189, Tokyo, Japan aut NATIONALLICENCE 700 1- Ohtsubo K. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 213-216 0001-6322 81:2<213 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer