caa a22 4500 465768814 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00334508 doi (NATIONALLICENCE)springer-10.1007/BF00334508 Axonal atrophy in the painful peripheral neuropathy in AIDS [Elektronische Daten] [G. Fuller, J. Jacobs, R. Guiloff] Summary: We compared the sural nerves from patients with AIDS; four with the painful peripheral neuropathy (PPN), three patients with non-painful distal symmetrical peripheral neuropathy (DSPN), one without clinical peripheral nerve involvement and two human immunodeficiency virus negative controls. Fibre diameter distributions showed a slight reduction in larger fibres in all patients with AIDS compared with controls. No significant difference was found in the relative frequency distribution of the lamellae counts between any of the groups. The relative frequency distribution of axonal area of myelinated fibres did not differ between controls, non-pailful DSPN or the patient without peripheral nerve involvement; however, all patients with PPN showed marked reduction in the number of axons of myelinated fibres of larger area which was significant when compared to each patient from the other groups (P<0.0001). This indicates that the reduction in larger fibres in PPN is mostly due to axonal atrophy rather than selective fibre loss. Axonal atrophy is associated with painful peripheral neuropathy in AIDS but not with those without pain. The possible role of axonal atrophy as a pathological substrate for pain is discussed. Springer-Verlag, 1990 AIDS nationallicence Pain nationallicence Neuropathy nationallicence Axonal atrophy nationallicence Fuller G. Department of Neuropathology, Institute of Neurology, Queen Square, WC1 N3BG, London, Great Britain aut Jacobs J. Department of Neuropathology, Institute of Neurology, Queen Square, WC1 N3BG, London, Great Britain aut Guiloff R. Department of Neurology, Westminster Hospital, Charing Cross and Westminster Medical School, 17 Page Street, SW1 2AP, London, Great Britain aut Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 198-203 0001-6322 81:2<198 1990 81 401 https://doi.org/10.1007/BF00334508 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00334508 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fuller G. Department of Neuropathology, Institute of Neurology, Queen Square, WC1 N3BG, London, Great Britain aut NATIONALLICENCE 700 1- Jacobs J. Department of Neuropathology, Institute of Neurology, Queen Square, WC1 N3BG, London, Great Britain aut NATIONALLICENCE 700 1- Guiloff R. Department of Neurology, Westminster Hospital, Charing Cross and Westminster Medical School, 17 Page Street, SW1 2AP, London, Great Britain aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 198-203 0001-6322 81:2<198 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer